Physiology lecture 3

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What genes control ABO and H?
ABO - chromosome 9, H - chromosome 19
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What does H code for? Is it dominant or recessive?
Dominant. Codes for fucosyl transferase enzyme (FUT1) that converts precursor substance in RBCs to H substance.
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What do the hh individuals show?
Bombay phenotype. May posses A or B genes but no FUT1 --> cannot make substance H
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What are the blood group antigens?
Agglutinogens
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What are the blood group antibodies?
Agglutinins
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What do the A and B alleles code for?
A: N-acetyl galactosamine transferase B: galactose transferase
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If the recipient of a blood donation contains antibodies against them what happens?
The RBCs of the individual will all agglutinate and eventually lyse - called haemolytic transfusion reaction
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What are individual with DD or Dd (rhesus)?
Rhesus +ve
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What are individuals with dd?
Rhesus -ve
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What happens if a mother is Rhesus -ve and a baby is Rhesus +ve?
The babies RBCs will cause the mother to develop antibodies to the D antigen (no problem with first child). If 2nd child is Rhesus +ve, the antibodies cross the placenta and attack RBCs of the baby. This destroys RBC and causes anaemia and jaundice
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Card 2

Front

What does H code for? Is it dominant or recessive?

Back

Dominant. Codes for fucosyl transferase enzyme (FUT1) that converts precursor substance in RBCs to H substance.

Card 3

Front

What do the hh individuals show?

Back

Preview of the front of card 3

Card 4

Front

What are the blood group antigens?

Back

Preview of the front of card 4

Card 5

Front

What are the blood group antibodies?

Back

Preview of the front of card 5
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