Postganglionic sympathetic fibres release noradrenaline acts on either a or b adrenoceptors
1 of 27
Noradrenaline
released by post-gangilonic sympathetic nerves
2 of 27
Adrenaline
Hormone secreted by adrenal gland
3 of 27
Dopamine
CNS transmitter and precursor of noradrenaline and adrenaline
4 of 27
Isoproterenol
Synthetic catecholamine
5 of 27
Catecholamines
Produced by chromaffin cells of the adrenal medulla and postganglionic fibres of sympathetic nervous system.
6 of 27
Adrenergic receptors
G protein-coupled receptors that target many catecholamines as well as beta blockers, B2 agonists and a2 agonists to treat high blood pressure.
7 of 27
SNS
Fight or flight response triggered by fear causing situations. Dilates pupils, increases heart rate, diverts blood from non essential organs to skeletal muscle.
8 of 27
a1
In the smooth muscle, causes vasoconstriction
9 of 27
a2
In nerve terminals, inhibition of transmitter release.
10 of 27
b1
In the heart, increase cardiac rate
11 of 27
b2
In skeletal muscle and nerve terminals, causes vasoconstriction and bronchodilation
12 of 27
b3
In skeletal muscle and fat, causes thermognesis and lipolysis
13 of 27
Unspecific B agonists
Used to treat heart failure, circulatory shock and anaphylaix
14 of 27
Unspecific B antagonists
Used to treat heart arrhythmia, heart failure, hyperthyroidism, migraine and glaucoma
15 of 27
NA
a-selective, causes vasoconstriction
16 of 27
ISO
b-selective predominantly causers vasodilation
17 of 27
Stimulation of baroreceptors
Causes depression of heart rate by enhancing vagus activity. Vasodilation by decreasing sympathetic activity.
18 of 27
Maintaining normal blood pressure
Decline -> stimulate vasomotor centre -> increase HR -> increase contractility -> increase peripheral resistance -> increase CO
19 of 27
Salbutamol
Opens up the medium and large airways in the lungs. Used to treat asthma through selective b2-adrenoceptors agonist causes bronchodilation
20 of 27
B2 receptor actions
Smooth muscle relaxation, lipolysis in adipose tissue, increase renin secretion in kidney.
21 of 27
B2 agonists
Used to treat asthma and COPD, hyperkalemia and preterm birth.
22 of 27
Atenolol
Beta blockers used to treat high blood pressure and the prevention of migraines. Through cardioselective b1-adrenoceptor antagonist
Comments
No comments have yet been made