The dose of the drug administered is clearly important, but more importantly it is the what?
Amount of drug in the blood that is free to bind at specific target sites (Bioavailability)
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What is the first factor that constitutes to the pharmokinetic component of drug action?
Routes of administration, how and where a drug is administered determines how quickly and how completely the drug is absorbed into the blood
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What is the second factor that constitutes to the pharmokinetic constitution?
Absorption and Distribution
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What does this mean?
A drug rarely acts where it initially contacts the body, it must pass through cell membranes and enter the blood plasma, which transports the drug to virtually all of the cells in the body
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What is the third factor that constitute towards Pharmokinetic bioavailability of the drug?
Binding
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What is binding?
Once in the blood plasma, some drug molecules move to tissues to bind to active target sites, A drug may also bind to plasma proteins or may be stored temporaily in bone or fat where it is inactive
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What is the fourth factor affecting drug action?
Inactivation
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What does this mean?
Biotransformation: Occurs primarily as a result of metabolic processes in the liver
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What is the final factor affecting drug action?
Excretion, the liver metabolites are eliminated from the body with urine or feces. Some drugs are excreted in an unaltered form by the kidneys
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Other cards in this set
Card 2
Front
What is the first factor that constitutes to the pharmokinetic component of drug action?
Back
Routes of administration, how and where a drug is administered determines how quickly and how completely the drug is absorbed into the blood
Card 3
Front
What is the second factor that constitutes to the pharmokinetic constitution?
Back
Card 4
Front
What does this mean?
Back
Card 5
Front
What is the third factor that constitute towards Pharmokinetic bioavailability of the drug?
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