Pharmacology of the NMJ - Medicine BM5 NLM1

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1. Metabolism of ACh in the synaptic cleft is rapid. Approximately what speed does it take place at?

  • 10x10^6 molecules per msec
  • 1x10^6 molecules per msec
  • 5x10^6 molecules per msec
  • 2.5x10^6 molecules per msec
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2. Select the correct example of an organophosphate.

  • Malathion
  • Tetrodotoxin
  • Edrophonium
  • Physostigmine

3. What is the duration of action of Suxamethonium?

  • ~5mins
  • ~10mins
  • ~20mins
  • ~30mins

4. Although Botulinum toxin is used cosmetically, what disease is it also used to help manage symptoms?

  • Parkinsons
  • Muscular Dystrophy
  • Cerebral Palsy
  • Alzheimers

5. Complete the sentence: Whole muscle contraction is...

  • ...a series of synchronous muscle fibre twitches
  • ...a partial response
  • ...a summation of the muscle fibre twitches
  • ...an annoying thing
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