Pharmacology of the NMJ - Medicine BM5 NLM1

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1. What is Vecuronium commonly used for?

  • Blood vessel relaxation (treatment of hypertension)
  • Muscle relaxation (anaesthesia)
  • Sphincter relaxation (laxative)
  • Prevent heart attacks (beta blocker)
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2. Although Botulinum toxin is used cosmetically, what disease is it also used to help manage symptoms?

  • Parkinsons
  • Cerebral Palsy
  • Alzheimers
  • Muscular Dystrophy

3. What emergency procedure is carried out on someone with organophosphate poisoning

  • Artificial respiration
  • Brain surgery
  • Defibrillation
  • Lumbar puncture

4. What is the mechanism of action of a large number of local anaesthetics?

  • They block the release of ACh by breaking down the ACh vesicles whilst they are still in the pre-synaptic knob
  • They block the sodium channels involved in propagating the nerve impulse
  • They block the action of AChE in breaking down ACh in the synaptic cleft
  • They block the calcium channels involved in propagating the nerve impulse

5. With regards to Vecuronium, complete the equation: Degree of Blockade =

  • Concentration of ACh/Concentration of Vecuronium
  • Concentration of Vecuronium/Concentration of ACh
  • Concentration of Vecuronium x Concentration of ACh
  • Concentration of ACh x Concentration of Vecuronium

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