Pharmacology of the NMJ - Medicine BM5 NLM1

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1. What is a Mini End Plate Potential (MEPP)?

  • A small depolarization that does not reach the threshold value, caused by ACh fusing without an axonal signal
  • A small depolarization that reaches the threshold value, caused by ACh fusing without an axonal signal
  • A small depolarization that does not reach the threshold value, caused by AChE fusing without an axonal signal
  • A large depolarization that does not reach the threshold value, caused by ACh fusing without an axonal signal
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2. Select the most correct statement about suxamethonium.

  • With a single low dose, it produces a complex 'dual block'
  • A possible side effect is tachycardia
  • It is chemically related to ACh but is not metabolised by AChE
  • It is an anaesthetic

3. Which of the following drugs should ber given to reverse the effects of organophosphate poisoning until new AChE can be generated?

  • Vecuronium
  • Atropine
  • Sarin
  • Suxamethonium

4. What is the mechanism of action of a large number of local anaesthetics?

  • They block the action of AChE in breaking down ACh in the synaptic cleft
  • They block the sodium channels involved in propagating the nerve impulse
  • They block the calcium channels involved in propagating the nerve impulse
  • They block the release of ACh by breaking down the ACh vesicles whilst they are still in the pre-synaptic knob

5. Which of the following enzymes break down suxamethonium?

  • Acetyl Cholinesterases
  • Suxamethonium Cholinesterases
  • Plasma Cholinesterases
  • Suxadeconstructases

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