Pharmacology lecture 8 0.0 / 5 ? BiologyPharmacokinetic conceptsUniversityNone Created by: willmiddlehamCreated on: 30-03-15 14:30 What is the study of pharmacogenomics? The association between GENOTYPE and RESPONSE to EXOGENOUS compounds 1 of 7 What are differences in drug metabolism and transport caused by? Genetic polymorphisms - SNP 2 of 7 How does a decrease in liver function affect PK? Decreases HEPATIC CLEARANCE and therefore TOTAL CL. Also and INCREASE in AUC and an INCREASE in HALF-LIFE. Doses of drugs adjusted on CHILD-PUGH SCORE 3 of 7 The amount of .......... ............ will affect drug distribution Adipose tissue 4 of 7 How does age affect PK? 1) Maturation of hepatic CYPs 2) Maturation of intestinal CYP3A 5 of 7 What is compartmental analysis based on? Tissues lumped together. How fast their concentrations reach equilibrium with blood concentration 6 of 7 What is physiology-based (PBPK) analysis? When each major organ/tissue of the body has its own compartment 7 of 7
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