Pharmacology lecture 12

What does stimulation of M3 receptors of the parasympathetic system do?
INCREASES IP3. Results in bronchoconstriction and increase mucus secretion
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What does stimulation of B2 receptors by adrenaline do?
INCREASES cAMP. Results in smooth muscle relaxation and bronchodilation.
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What does inhibitory NO do on bronchial smooth muscle?
Smooth muscle relaxation and bronchodilation
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What does excitatory substance P and neurokinin A, on bronchial smooth muscle do?
Smooth muscle contraction and bronchoconstriction
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What are the 3 effects of asthma?
1) Acute airway obstruction caused by contraction of the airway smooth muscle 2) Mucus hypersecretion and thickening 3) Airway inflammation
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What are the 2 phases of asthma?
Immediate phase and late/delayed phase
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What goes on during the immediate phase of asthma?
Bronchoconstriction / Interaction with mast cells / Release of spasmogens - histamine, leukotrienes / Bronchospasm / Release chemotaxins, LTB4 attraction of leucocytes
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What goes on during the late/delayed phase of asthma?
1) Progressing inflammatory response - vasodilation, oedema, and mucus secretion 2) Influx of cytokine releasing lymphocytes and eosinophils - long lasting damage to bronchial tissue, hyper reactivity of bronchial tissue
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What are 3 bronchodilators?
B2 agonists, muscarinic antagonists, xanthines
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How are B2 agonists given, what do they do and what are the side effects?
Inhalation, dilate the bronchi - inhibits mediator release from mast cells, side effects: tolerance and tremor
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What does stimulation of the B2 receptor do?
Activation of adenylyl cyclase, increased cAMP, smooth muscle relaxation and bronchodilation
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What do xanthines do?
Bronchodilation - blocks phosphodiesterase III and IV, increases cAMP. Anti-inflammatory properties
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What do muscarinic antagonists do?
Block M3 mediated bronchoconstriction - dilate bronchi. Block M3 mediated smooth muscle contraction - decrease mucus secretion
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Give an example of a muscarinic antagonist and how it is administered.
Ipratropium - given by inhalation
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What do glucocorticoids do?
Induce synthesis of polypeptide lipocortin which inhibits phospholipase A2 so decrease production of inflammatory mediators --> Suppress the inflammatory response
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Give an example of a glucocorticoid, how it is given and the side effects
Beclomethasone, inhalation, oral candidiasis and Cushing like syndrome
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What does sodium cromolyn prevent?
The release of histamine and inflammatory mediators. Inhibit hyper-responsitivity
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What do drugs used for coughs do?
1) DECREASE sensory receptors sensitivity 2) DECREASE sensitivity of cough centre in the brain (hypothalamus) - opiate receptor agonists, codeine
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Other cards in this set

Card 2

Front

What does stimulation of B2 receptors by adrenaline do?

Back

INCREASES cAMP. Results in smooth muscle relaxation and bronchodilation.

Card 3

Front

What does inhibitory NO do on bronchial smooth muscle?

Back

Preview of the front of card 3

Card 4

Front

What does excitatory substance P and neurokinin A, on bronchial smooth muscle do?

Back

Preview of the front of card 4

Card 5

Front

What are the 3 effects of asthma?

Back

Preview of the front of card 5
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