What is the effect of a nicotinic agonist on the muscle?
Initial depolarisation and contraction. Agonists NOT metabolised. Fibre is persistently depolarised resulting in the loss of function and further excitability - depolarising block. (paralysis/muscle relaxation)
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What is the effect of a nicotinic antagonist on the muscle?
Hyperpolarisation, inhibition of EPPs. Muscle fibre relaxation (paralysis)
14 of 18
Name two muscarinic antagonists and what they do.
1) Tropicamide - pupil dilation in eye surgery (2-6hrs) 2) Atropine pupil dilation and oral/respiratory secretions
15 of 18
What inhibits ACh release?
Botulinum toxin
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What does anti-cholinesterase do to the ANS?
INCREASE transmission at parasympathetic postganglionic synapses
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What does anti-cholinesterase do to the NMJ?
Increase muscle tension and twitching. Large doses can cause a depolarising block
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Other cards in this set
Card 2
Front
What neurotransmitter is released at the postganglionic neurone on the sympathetic system?
Back
Noradrenaline - NA
Card 3
Front
What neurotransmitter is released at the preganglionic neurone on the parasympathetic system?
Back
Card 4
Front
What neurotransmitter is released at the postganglionic neurone on the parasympathetic system?
Back
Card 5
Front
What are the 4 main effects of the sympathetic nervous system?
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