Pharmacology lecture 10

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What neurotransmitter is released at the preganglionic neurone on the sympathetic system?
Acetylcholine - ACh
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What neurotransmitter is released at the postganglionic neurone on the sympathetic system?
Noradrenaline - NA
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What neurotransmitter is released at the preganglionic neurone on the parasympathetic system?
Acetylcholine - ACh
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What neurotransmitter is released at the postganglionic neurone on the parasympathetic system?
Acetylcholine - ACh
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What are the 4 main effects of the sympathetic nervous system?
1) Pupils DILATE 2) Airways in lungs DILATE 3) Respiratory rate INCREASES 4) Heart rate INCREASES
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What are the 4 main effects of the parasympathetic nervous system?
1) Pupils CONSTRICT 2) Airways in lungs CONSTRICT 3) Respiratory rate DECREASES 4) Heart rate DECREASES
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Name the two ACh receptors
1) Muscarinic 1,2,3 2) Nicotinic
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Where is the muscarinic receptors located at? and what kind of receptor are they?
The postganglionic parasympathetic synapses. G-protein coupled (slow response)
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What type of receptor is the nicotinic receptor?
Ligand-gated ion channels (fast)
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What do nicotinic agonists cause on the sympathetic nervous system?
Vasoconstriction, tachycardia, hypertension
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What do nicotinic agonists cause on the parasympathetic nervous system?
Bradycardia, hypotension, increased GI motility, increased secretions
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Name two muscarinic agonists and what do they do?
1) Pilocarpine - contraction of sphincter muscle ie. pupil constriction 2) Carbachol
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What is the effect of a nicotinic agonist on the muscle?
Initial depolarisation and contraction. Agonists NOT metabolised. Fibre is persistently depolarised resulting in the loss of function and further excitability - depolarising block. (paralysis/muscle relaxation)
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What is the effect of a nicotinic antagonist on the muscle?
Hyperpolarisation, inhibition of EPPs. Muscle fibre relaxation (paralysis)
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Name two muscarinic antagonists and what they do.
1) Tropicamide - pupil dilation in eye surgery (2-6hrs) 2) Atropine pupil dilation and oral/respiratory secretions
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What inhibits ACh release?
Botulinum toxin
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What does anti-cholinesterase do to the ANS?
INCREASE transmission at parasympathetic postganglionic synapses
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What does anti-cholinesterase do to the NMJ?
Increase muscle tension and twitching. Large doses can cause a depolarising block
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Card 2

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What neurotransmitter is released at the postganglionic neurone on the sympathetic system?

Back

Noradrenaline - NA

Card 3

Front

What neurotransmitter is released at the preganglionic neurone on the parasympathetic system?

Back

Preview of the front of card 3

Card 4

Front

What neurotransmitter is released at the postganglionic neurone on the parasympathetic system?

Back

Preview of the front of card 4

Card 5

Front

What are the 4 main effects of the sympathetic nervous system?

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