Pharmacology lecture 1

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  • Created by: Amh
  • Created on: 02-02-16 11:00
What is pharmacodynamics
is essentially the effect of a drug on the body, what a drug dioes from a therapeutic perspective - what receptor is it interacting
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What is pharmacokinetics
the effect of the body on drugs. How the body moves the drug. Kinetics influences dynamics. How the body handles the drug e.g. metabolism The 2 are closely related.
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What is an agonist
a compound that bnds to a particular receptor (recognition site e.g on a protein)and brings about a response
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What is an antagonist
a compound binds to a receptor and inhibit a repsponse (blocks transduction mechanisms). in man y cases act at recognition site where an endogenous ligand normally acts.
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What is occupancy
how many of the receptors are bound
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what is affinity
how easily a compond binds too the recognition site. HIgh - binds easily, so you would only need a low conc.
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What it efficacy
functional aspects, a high affinity antoagonist might bind v easily achieving maximum occupancy - this has zero efficacy. Eff = functional response. Efficacy is refering to functional response and what happens down stream Antagonists block down stre
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What is potency
Another functional measure. an indication of strenth of the compond in respect to functional consideration.
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What is the difference between efficacy and potency
If we had a number of comp and they all produce a maximal response. i f we take 50% of this maximal response we can look at which drug is most potent ie brings about the 50% response at lowest conc.
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What are the 4 main targets for drug effects
1 receptors, 2 ion channels, 3 enzymes 4 transporters
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What is the most common target for drug effect
Receptors
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Card 2

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What is pharmacokinetics

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the effect of the body on drugs. How the body moves the drug. Kinetics influences dynamics. How the body handles the drug e.g. metabolism The 2 are closely related.

Card 3

Front

What is an agonist

Back

Preview of the front of card 3

Card 4

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What is an antagonist

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Card 5

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What is occupancy

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