is essentially the effect of a drug on the body, what a drug dioes from a therapeutic perspective - what receptor is it interacting
1 of 11
What is pharmacokinetics
the effect of the body on drugs. How the body moves the drug. Kinetics influences dynamics. How the body handles the drug e.g. metabolism The 2 are closely related.
2 of 11
What is an agonist
a compound that bnds to a particular receptor (recognition site e.g on a protein)and brings about a response
3 of 11
What is an antagonist
a compound binds to a receptor and inhibit a repsponse (blocks transduction mechanisms). in man y cases act at recognition site where an endogenous ligand normally acts.
4 of 11
What is occupancy
how many of the receptors are bound
5 of 11
what is affinity
how easily a compond binds too the recognition site. HIgh - binds easily, so you would only need a low conc.
6 of 11
What it efficacy
functional aspects, a high affinity antoagonist might bind v easily achieving maximum occupancy - this has zero efficacy. Eff = functional response. Efficacy is refering to functional response and what happens down stream Antagonists block down stre
7 of 11
What is potency
Another functional measure. an indication of strenth of the compond in respect to functional consideration.
8 of 11
What is the difference between efficacy and potency
If we had a number of comp and they all produce a maximal response. i f we take 50% of this maximal response we can look at which drug is most potent ie brings about the 50% response at lowest conc.
9 of 11
What are the 4 main targets for drug effects
1 receptors, 2 ion channels, 3 enzymes 4 transporters
10 of 11
What is the most common target for drug effect
Receptors
11 of 11
Other cards in this set
Card 2
Front
What is pharmacokinetics
Back
the effect of the body on drugs. How the body moves the drug. Kinetics influences dynamics. How the body handles the drug e.g. metabolism The 2 are closely related.
Comments
No comments have yet been made