Pharmacology exam

?
  • Created by: Cal1234
  • Created on: 03-06-20 14:11
What does MDR1 stand for
Multidrug resistance mutation
1 of 37
What is MDR1
A mutation at the MDR1 gene that makes animals more sensitive to the negative effects of certain medications
2 of 37
What is the reference for MDR1 gene
Barnette, 2020
3 of 37
What is flea allergic dermatitis
An allergic reaction to flea saliva injected by bites from fleas
4 of 37
What are the two references for FAD
(Anderson, 2018) (Elsheika, 2012)
5 of 37
What are the active ingredients of Advantix
Imidacloprid and Permethrin
6 of 37
How does imidacloprid work
Has high affinity for acetylcholine receptors in the post synaptic region of the CNS, results in paralysis and death
7 of 37
How does permethrin work
Affects the voltage gates sodium channels, by slowing both activation and inactivation properties leading to hyperexcitability and death
8 of 37
what legal category is Advantix
POM-V
9 of 37
What is the reference for Advantix
(NOAH, 2019)
10 of 37
What is the active ingredient in Bravecto
Flualaner
11 of 37
How does Flualaner work
It is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand gated chloride channels (GABA receptor and glutamate receptor)
12 of 37
What happens to Flualaner in the body
It is readily absorbed and systemically distributed, reaches highest concentrations in fat followed by liver, kidney and muscles
13 of 37
How is bravecto excreted
The prolonged elimination and lack of extensive metabolism means there is effective concentration for 3 months, the major rout of elimination is via the faeces
14 of 37
what legal category is bravecto
POM-V
15 of 37
What is the reference for Bravecto
(NOAH, 2019)
16 of 37
What is the active ingredient in Droncit
Praziquantel
17 of 37
How does praziquantel work
Impairs the normal tegument function of the parasite making it permeable to excessive glucose loss and so more easily attacked by prolteolytic enzymes
18 of 37
How is praziquantel excreted
It is readily absorbed and metabolized by the liver and excreted entirely as metabolites in urine and faeces
19 of 37
what is the reference for Droncit
NOAH, 2019
20 of 37
What legal category is droncit
AVM - GSL
21 of 37
what is prednisolone
A synthetic glucocorticoid with anti-inflammatory and immunosuppressant properties
22 of 37
How does prednisolone absorb and excreted
Readily absorbed from GI tract, peak plasma concentration is reached in one to two hours, extensively bound to plasma proteins, excreted in urine as free and conjugated metabolites
23 of 37
What legal category is prednisolone
POM-V
24 of 37
What hormones do glucocorticoids contain
cortisol and cortisone
25 of 37
how are the antiinflammatory effects of glucocorticoids brought about
by the ability to block the enzyme phospholipase
26 of 37
5 ways in which glucocorticoids protect cells from inflammatory trauma
Stabilise cell membranes, stabilize lysosomal membranes, disrupt histamine synthesis, inhibit interleukin synthesis and reduce exudative processes
27 of 37
4 ways in which glucocorticoids suppress the immune system in allergic conditions
Inhibit antibody formation, Decrease concentration of lymphocytes and eosinophils, suppress the migration of neutrophils, inhibit phagocytosis
28 of 37
What are the adverse side effects of glucocorticoids
Iatrogenic Cushing's - hyperadrenocorticism, PUPD, muscle wastage and thinning of skin, polyphagia with resultant weight gain
29 of 37
what is the reference for corticosteroids
Wanamaker and massey, 2015
30 of 37
What ingredients in antiparisitics are collies sensitive to
ivermectin, moxidectin, selamectin and milbemycin
31 of 37
Why are collies sensitive to the ingredients
They are all macrolytic lactones which the method of action lists CNS disorders as side effects with the MDR1 gene mutation is sensitive to
32 of 37
What ingredients does the indorex spray contain
Permethrin and pyriproxyfen
33 of 37
What is another reference for ectoparasites
(Lau-Gillard, 2012)
34 of 37
References for legalities
BSAVA, 2019, Veterinary medicines directorate 2019, veterinary medicines regulations, 2013,
35 of 37
What are pharmacodynamics
The effect of the drug on the organism
36 of 37
What are pharmacokinetics
The effect of the body on the drug
37 of 37

Other cards in this set

Card 2

Front

What is MDR1

Back

A mutation at the MDR1 gene that makes animals more sensitive to the negative effects of certain medications

Card 3

Front

What is the reference for MDR1 gene

Back

Preview of the front of card 3

Card 4

Front

What is flea allergic dermatitis

Back

Preview of the front of card 4

Card 5

Front

What are the two references for FAD

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Other resources:

See all Other resources »See all Pharmacology resources »