Pharmacology 2

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What are the traditional methods to producing a new drug?
1. Basic information of what you want to produce the drug for, eg. to remove pain. 2. Idea- remove prostaglandins from being synthesised 3. hypothesis a chemical to block this called an analgesics.
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What is the system now?
An assay system which measures something, eg. the amount of prostaglandins. Use this to find chemicals that help and identify an active chemical.
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Identifying an active chemical, what could it be?
1. natural 2. from conventional chemical synthesis - a known pathway to synthesis the chemical. 3. combinational chemical synthesis - react lots of chemicals together to find one that works 4. can now use algorithms to predict new drugs,
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Once a active chemical has been identified what is the next step?
Add different structures to it to see how it could optimise the drug. Check pharmacokinetics for absorption etc. Check toxicity. If safe then clinical trials.
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What are the four stages of clinical trials?
0. (cancer trials) using human tissue to check is the drug targets the correct area using a minute dose. 1. Small scale on healthy volunteers to check for side effects 2. Patient volunteers for effectiveness. 3. Large scale patient volunteers for...
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Continued answer.
for comparison with current available medicines. Registration of new drug. 4. post studies to test long term safety and unpredictable variation in different populations
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Card 2

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What is the system now?

Back

An assay system which measures something, eg. the amount of prostaglandins. Use this to find chemicals that help and identify an active chemical.

Card 3

Front

Identifying an active chemical, what could it be?

Back

Preview of the front of card 3

Card 4

Front

Once a active chemical has been identified what is the next step?

Back

Preview of the front of card 4

Card 5

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What are the four stages of clinical trials?

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