Pharmaceutical capsules 0.0 / 5 ? PharmacyPharmaceutical capsulesUniversityNone Created by: SamDaviesCreated on: 05-04-19 20:07 3108964175 Across 1. This type of capsule has its shell made out of gelatin powder mixed with water, glycerin and a colouring (4, 3) 5. A lightly compressed powder that can be used to fill capsules (4) 6. Does oxygen permeability increase or decrease with humidity and glycerol content (8) 9. Gelatin prepared by treating bone and tissue with hydrochloric acid to dissolve the calcium compounds (4, 1) 10. These excipients make soft-gel capsule shells flexible and elastic which are added to the shell formulation before drying. Examples: Glycerin, sorbitol, propylene glycol (11) Down 1. This type of capsule uses a fill temperature of 35 degrees and has a less effective barrier to water, light and oxygen (4, 3) 3. Test which determines if the gelatin is good enough to be used in capsules. The resistance of the gelatin gel to a probe is measured - 250g for hardshell capsules and 150g for soft shell capsules (5, 8) 4. An alternative shell material to gelatin which is of a vegetarian source, has a similar disintegration, dissolution, moisture content and transparency as gelatin, and has a good barrier to oxygen (8) 7. Gelatin obtained from swine skins (4, 1) 8. An industrial capsule filling system where a stainless steel cylinder with a spring loaded piston is lowered into a powder bed. The powder is forced up into the cylinder to form a plug. The plug is then released into the capsule shell (7)
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