Oncogenes 0.0 / 5 ? BiologyCancerUniversityNone Created by: FitzaliceCreated on: 05-05-18 16:21 SH2 domain recognises what Phosphorylated Tryosines 1 of 16 SH3 domain recognises what Proline rich region 2 of 16 Residue of regulatory Tryosine in SRC kinase Y527 3 of 16 Residue of activatory Tryosine in SRC kinase Y416 4 of 16 PI3K has what domains P110 (catalytic) and P85 (regulatory) 5 of 16 How does AKT/PKB bind PIP3 via PH domain 6 of 16 what does PTEN do Convert PIP3 to PIP2 7 of 16 what does PDK1 and PDK2 do activate AKT/PKB through phosphorlyation 8 of 16 Ras signalling activity IS context dependent within cells and microenvironment 9 of 16 Is a single oncogenic mutation sufficient to drive cancer NO 10 of 16 How do Myc and RAS cooperate Ras overcomes Myc induced apoptosis and Myc overcomes RAS induces senescence 11 of 16 Tamoxifen mouse allows what controlled expression of Myc 12 of 16 Ras can also promote proliferation via what pathway ERK/ MEK pathway 13 of 16 How does Ras stabilise Myc phosphorylation of S62 and T58 14 of 16 Myc does not do what Promote differentiation 15 of 16 Myc does not do what Promote senescence 16 of 16
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