iNHIBITION of Synthesis of neurotransmitter has a...
very SLOW onset of action
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An example of enhancing synthesis
L-dopa, which is a dopamine precursor to enhance dopamine production in Parkinsons
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An example of vesicle disruption that can lead to leakage of neurotransitter from nerve terminals
Amphetamines lead to leakage of noradrenaine from noradrenergic terminals
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Ways that release of NT can be inhibited
Blockage of VOCC's by w-conotoxin.
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How has w-conotoxin been used experimentally?
as an analgesic
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What are autoreceptors?
Receptors that mediate feedback of neurotransmitters on its own release process.
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What are heteroreceptors?
Receptors that mediate the inhibitory effects of one neurotransmitters on the release process of another
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Examples of autoreceptors
a2-adrenoreceptors
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examples of heteroreceptors
opioid receptors
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What will antagonists at pre-synaptic inhibitory receptors do?
INCREASE the release of neurotransmitter
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What type of receptor is the GABAa receptor?
Ionotropic
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What kind of receptor is the 5HT3 receptor?
Ionotropic
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What kind of receptor is the d1-d5 receptor
metabotropic
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What kind of receptor is the NMDA and AMPA glutamate receptors
ionotropic
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What does pencyclidine do?
Non-competative antagonist that clocks the channel of the NMDA receptor
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What needs to bind to NMDA receptors for them to activate?
glutamate and glycine as co-aginists
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Which receptor does benzodiazapine bind to?
GABAa
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How does three types of binding to BDZ site alter the effects of GABA
agonists - potentiate the effect. Inverse agonists - inhibit the actions of GABA. antagonists - block the effects of BDZ agonists but has no effect on GABA
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