Neurodegeneration pharm 0.0 / 5 ? BiologypharmUniversityNone Created by: AmhCreated on: 20-05-16 11:39 What causes parkinsons A loss of dopaminergic neurons 1 of 29 How many neurons are destroyed before the onset of symptoms 70% 2 of 29 Where do these dopaminergic neurons arise Substantia nigra 3 of 29 What 2 neurotransmitters are involved in movement Dopamine, acetylcholine 4 of 29 what happens when dopamine is depleted acetycholine transmission predominates leading to involuntary spontaneous contrtol 5 of 29 What are the 4 main dopamine pathways Nigrostrital, Meslimbicm mesocorticol, pit gland path 6 of 29 What pathway is affected by parkinsons Nigrostriatal pathway, cell bodies in the substantia niagra whose bods terminate in corpus striatum 7 of 29 Whar are the dopamine receptors ` 2 families of GPCR 8 of 29 What is the D1 family of ereceptors D1, D5 , These increase adenylate cyclase, they are excitatory 9 of 29 what is the D2 family of receptors Decrease Adenylate cyclase and IP3 THEY ARE IN HIBITORY 10 of 29 What do dopamine neurons in the nigrostriatal pathway do these are d1 and d2 neurons , which inhbit cholinergic transmission and therefore are important in motor con trol 11 of 29 what does dopamine in the pit gland do dopamine inhibit prolactin release 12 of 29 What does dopamine in the mesolimbic pathway do involved in emotion, implicated in psychosis 13 of 29 what are the symptoms of parkinsons Resting tremor, slowness bradykinesia, hypokinesia, muscle rigidity, shuffle gait 14 of 29 What does the damage route from damage intiiatlly result from protein misfolding aggregation of protein that can disrupt neuronal function leading to cellular destruction , mitochondria misfunction oxiadative stress inflammation apoptosis 15 of 29 What drugs can cause parkinson like symptoms Neurotoxins, dopamine antagonists (antipsychotics), depletion (reserpine) 16 of 29 What is MPTP An early 80s heroin substitute 17 of 29 What is MPTP coverted to in the boody Pyridinium ion by MAO in Dopamin neurons and this produces oxidative stress. , met is inhibited by selegiline 18 of 29 what are the treatment options in parkinsons dopamine replacing agents, agents reduce dopamine metabolism, dopamine agonists, dopamine releasers, and cholinergic blockers 19 of 29 What is an example of a dopamine replacing agents L-DOPA (levodopa) 20 of 29 Give an example agents reduce dopamine metabolism Selegeline 21 of 29 Give an example of a dopamine agonists, bromocroptine, apomorphine 22 of 29 Give an example of dopamine releasers amatadine 23 of 29 Give an example of cholinergic blockers q 24 of 29 What is the first line treatment for parkinsoons L-DOPA (levodopa) and DOPA carboxylase inhibitro to prevent LDOPA side effects in periphery 25 of 29 Where is L DOPA well absorbed intestine 26 of 29 what are the adverse effects of L-DOPA DYskinesia, On of faffects, nausea, hypotension, psychosees 27 of 29 Why would you use COMT inhibitors To reduce the peaks to smooth out the peaks 28 of 29 whata re the old dopamine agonists and what are the new dopamine agonists Old= bromocriptine and pergolide, new = more selective pramipexole and ropinirole 29 of 29
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