hippocampal volume loss and untreated depression, increased metabolic activity in amygdala and orbitofrontal cortex
1 of 8
Sullivan et al., (2000)
extent to which depression is inherited- to a large degree
2 of 8
Bertelsen, (1977)
concordance rate for mood disorders among identical and fraternal twins- mz dz, any mood disorder 60,20, s,dep 60,30, dep 36,18, bipolar 80, 18
3 of 8
Seligman, (1975)
learned helplessness theory- Learned helpless animals show biological features of depression- REM sleep alterations, loss of bodyweight, diminished sexual activity elevated corticosterone.
4 of 8
Weiss et al 1975)
NA reduced shortly after exposure to inescapable shock, but recovers over the next 48 hrs suggests reason Seligman's dogs didnt show helplessness when tested 48 hr after uncontrollable shock was because brain NA norm again
5 of 8
Caspi et al., (2010)
evidence that genetic variation in gene for serotonin transporter assoc with dep/axn
6 of 8
Sora et al 2001)
Mice lacking both SERT and DAT no place preference for cocaine suggesting SERT involvement in cocaine effects on reward
7 of 8
Holsboer , 1996)
Depression is associated with increased activity of the HPA axis
8 of 8
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Card 2
Front
Sullivan et al., (2000)
Back
extent to which depression is inherited- to a large degree
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