neuro alz

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  • Created by: freya_bc
  • Created on: 27-04-18 11:11
Abbott (2011)
More cases because living longer Going to get higher in Europe few treatments available
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Perrin et al., (2009)
different trajectories of neuronal integrity (decreases) amyloid plaques (increases) and neurofibrillary tangles (increase)
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Blessed, Tomlinson and Roth, (1968)
Plaque counts did not follow very strictly – less than 5 no dementia at all – those below 5 had normal test scores but still had diag- had varying no of plaques- no cog issues but had plaques- plaques not fully conducive to cognitive function impairm
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Sunderland et al., (2003)
Reduced Ab and increased Tau in cerebrospinal fluid from people with Alzheimer’s Disease. its decreased - this is thought to be because the Ab is being deposited in plaques. “amyloid sink” Increase tau protein in CSF Can physically measure levels
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Karran et al., (2011)
amyloid cascade hypothesis
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Riedel et al.,(2016)
Sex-specific incidence estimates of Alzheimer’s per 1000 person years. 1000 person years : used in epidemiology the number of new cases of disease or injury during specified period / time each person was observed, totalled for all persons
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Bateman et al., (2012)
Pet studies Abeta peptide in autosomal domin- fam inheritance alz A-b peptide visualised in autosomal dominant Alzheimer’s Disease
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Snowdon et al
nun study- Prevalence of dementia in those with AD (ie abundant plaques and tangles) : 93% with infarcts in areas basal ganglia,thalmus 57% without infarcts
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Bartus (1982)
cholinergic hypo of geriatric memory dysfunction
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Moran et al., (1995)
Mice expressing human form of Amyloid precursor protein with a mutation known to cause familial AD have age-dependent disrupted spatial memory in water maze- Randomly swimming round the edge – disrupted spatial memory – only happened to older mice
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Perrin et al., (2009)

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different trajectories of neuronal integrity (decreases) amyloid plaques (increases) and neurofibrillary tangles (increase)

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Blessed, Tomlinson and Roth, (1968)

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Sunderland et al., (2003)

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Karran et al., (2011)

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