Because its expression is controlled by ions. It then controls ion homeostasis itself, and is then inhibited by an ion that co-localises with a product of its metabolism.
1 of 5
There are 3 major isoforms of APP. Which is the one that is most enriched in neurons and most associated with AD?
APP695
2 of 5
Why is metal binding activity thought to play a role in abeta toxicity?
Addition of ion chelators to PCN reverses toxicity elements
3 of 5
Why is Mouse abeta not as toxic as human abeta?
Due to lack of extra his in metal binding region
4 of 5
what happens when tau is hyperphosphorylated?
It lacks affinity for microtubules, becomes insoluble, self-associates
5 of 5
Other cards in this set
Card 2
Front
There are 3 major isoforms of APP. Which is the one that is most enriched in neurons and most associated with AD?
Back
APP695
Card 3
Front
Why is metal binding activity thought to play a role in abeta toxicity?
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