Morphogenesis in Development

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Morphogenesis
Form generation
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EMT
Basal lamina broken down, cells elongated, breaks intra-cellular connections, bottle shaped, cells no longer connected to others
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MET
Squeezes in between epithelial cells, makes connections, resynthesizes the basal lamina.
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EMT & MET
Allows cells to break away and migrate to form new strcutures
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Myoblasts
Limb muscle precursors, migrate to lay down the muscle pattern
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Cytoskeleton
Attract and repulse cells guiding them to migrate on the right path.
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Pigment defects
Melanocytes in the skin
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Repulsive interactions
Set up tissue boundaries e.g Eph (receptor) and Ephrin (ligand)
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Convergent extension
Tissue of an embryo is reconstructed to converge along one axis and extend along the perpendicular axis by cellular movement. The anteroposterior axis extends and lateral tissues move in towards the dorsal mid-line. Gives the body shape
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Creating form
End of 3rd week, the embryo is a flat disk. Growth allows the embryo to fold and generate the vertebrate body plan.
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Folding
Form nervous system
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Budding
Generates respiratory system
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Hollowing
Involved in nervous system
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Assembly
Used in heart development
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Morphogen
Substance whose non-uniform distribution governs the pattern of tissue development. One morphogen can specify differentiation of several cell types.
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Formation of rudimentary nervous system
Primitive neural cells - rudimentary CNS tube - differentiate into neurons whilst stem cell pool divides.
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Other cards in this set

Card 2

Front

Basal lamina broken down, cells elongated, breaks intra-cellular connections, bottle shaped, cells no longer connected to others

Back

EMT

Card 3

Front

Squeezes in between epithelial cells, makes connections, resynthesizes the basal lamina.

Back

Preview of the back of card 3

Card 4

Front

Allows cells to break away and migrate to form new strcutures

Back

Preview of the back of card 4

Card 5

Front

Limb muscle precursors, migrate to lay down the muscle pattern

Back

Preview of the back of card 5
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