Monoamines - dopamine 0.0 / 5 BiologyPharmacologyUniversityNone Created by: Annabel ForsdykeCreated on: 20-05-15 10:27 List the monoamine neurotransmitters Dopamine, noradrenaline, 5-HT, 1 of 35 What is a monoamine neurotransitter? neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain 2 of 35 List the main dopaminergic pathways in the brain Nigrostriatal, mesolimbic, mesocortical pathway, tuberoinfundibular, retina, olfactory tubercule. 3 of 35 Some particuarly important processes that dopamine is needed for movment control (nigrostriatal), emotion (mesocortical), reward (mesolimbic), addiction (mesolimbic) 4 of 35 What is dopamine formed from? Tyrosine. 5 of 35 What enzyme acts on tyrosine and what does it make? Draw it. Tyrosine hydroxylase, makes L dopa. 6 of 35 What happens to L DOPA then dopa decarboxylase acts to make dopamine 7 of 35 Two enzymes that can metabolise dopamine Monoamine oxidase a/b, or Catechol-o-methyltransferase. in either order 8 of 35 If MOAa acts first what do you get DOPAC and then homovanillic acid 9 of 35 If COMT acts first what do you get 3-methoxy-tyramine, into homovanillic acid 10 of 35 How is dopamine take up into the post synaptic terminal DAT 11 of 35 What is the DAT transporter like Na+/Cl- dependant symporter. 12 of 35 How many transmembrane segements does it have, how many AAs 12, 617 13 of 35 Examples of DAT blockers Benzotropine, cocaine, methylphenidate, GBR12909 14 of 35 What is the VMAT2 transporter like H+ dependant vesicular membrane transporter. 15 of 35 transmembrane segments and amino acids 12, 742 16 of 35 blockers of the VMAT2 reserpine, tetrabenzine 17 of 35 Which Dopamine receptors are in the D1 family D1 and D5. 18 of 35 What is the intracellular effect of activating D1 like receptors Gs coupled, results in an increase in cAMP. 19 of 35 What pathways are D1 receptors found in cortex, for arousal and mood, limbic, for emotion, striatum for motor control. 20 of 35 What D recetpors are D2 like D2, D3, D4. 21 of 35 What is the intracellular effect of D2 family receptor activation Gi coupled. decrease cAMP, and or increase IP2, increase K, decrease calcium 22 of 35 What is apomorphine, what receptors does it prefer an agonist at D receptors, greater affinity for D2 family. Reduces firing rate when acting presynaptically 23 of 35 bromocriptine is what kind of drug at D receptors a partial agonist at D1 like, a full agonist at D2like 24 of 35 An antagonist with medium affinity for all D receptors clozapine. 25 of 35 Two antagonists that have no affinity for D1, but high affinity for D2 like Spiperone, Sulpiride 26 of 35 An antagonist that has no affinity for D2 but high affinity for D1 skf38393 27 of 35 What does cocaine do inhibits dopamine uptake, used as a stimulant 28 of 35 Methylpenidate, amphetamine Displaces DA from vesicles, Increases DA release, Inhibits uptake, MAO inhibitor. Use as a stimulant and can induce psychosis 29 of 35 Four dopamine agonists Apomorphine, ropinirole, rotigotine, pramipexole - treat parkinsons or restless leg 30 of 35 Dopamine antagonists Phenothiazines Butyrophenones Spiperone Sulpiride Clozapine, treat schizophrenia 31 of 35 What pathway degrades in parkinsons nigrostriatal pathway 32 of 35 what pathway is important in addiction and drug dependance mesolimbic pathway 33 of 35 What pathway is important in psychosis and ADHD mesocortical 34 of 35 What does the tuberoinfundibular pathway do inhibits prolactin release - dopain antgaonists cause gynacomastia 35 of 35
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