Monamines part 2 0.0 / 5 ? BiologyPharmacologyUniversityNone Created by: Annabel ForsdykeCreated on: 20-05-15 10:52 the two major noradrenergic nuclei locus coeruleus, caudal raphe nuclei 1 of 35 Describe the locus coeruleus projections project to the frontal cortex, thalamus, hypothalamus and limbic system. also back to the cerebellum 2 of 35 Describe the projection of the caudal raphe nuclei ascend to the amygdala and descend through the spinal cord 3 of 35 What are these two nuclei involved in arousal and mood 4 of 35 How is noradrenaline formed Dopamine B hydroxylase acts on dopamine to form noradrenaline 5 of 35 How is noradrenaline metabolised COMT and MAOa, in either order 6 of 35 if COMT acts first what do you get normetanephrine, and then vaillylmandelic acid, secreted in urine. 7 of 35 if MAOa acts first what do you get dihydroxymadelic acid,then vanillymandelic acid 8 of 35 How does noradrenaline get back into the terminal NET 9 of 35 What is the NET transporter like Na, Cl- dependant symporter. 12 TMD, 620 amino acids. 10 of 35 Blockers of the NET Nisoxetine, desipramine, atomoxetine, cocaine. 11 of 35 How is noradrenaline taken into the vesicle VMAT2 12 of 35 The types of adrenergic receptors a1, a2, b1, b2. 13 of 35 What is the presynaptic effect of a1 receptor activation depolarisation and burst firing, 14 of 35 What is the presynaptic effect of a2 receptor activation Inhibit transmitter release Inhibit voltage dependent Calcium channels Inhibit adenylate cyclase 15 of 35 What is the POST synaptic action of A1 receptor activcation activate PLC Increase IP3 and DAG, by Gq/11 coupling. 16 of 35 What is the post synaptic action of A2 binding iInhibit adenylate cyclase Activate K+ channels ↑K+ efflux, by Gi/go coupling 17 of 35 Post synaptic effect of B1 and B2 binding. Activate adenylate cyclase ↑cAMP by Gs coupling 18 of 35 Drugs that displace NA and reduce NA uptake amphetamines and methylphenidate. 19 of 35 How does cocaine affect noradrenaline inhibits NET transporter. 20 of 35 Noradrenaline agonists isoprenaline, salbutamol, phenylephrine, clonidine 21 of 35 antagonists at NA receptors Phentolamine. Prazocin, Yohimbine, practolol, butoxamine 22 of 35 SEROTONIN - What's it's distribution in the CNS like it resembles NA 23 of 35 Principle serotonergic nuclei rostral and caudal raphe nuclei. Sleep, wakefullness, mood, hallucinations, behaviour, feeding. 24 of 35 How is serotonin formed from Tryptophan, catalyised to 5 hydroxytryptophan by tryptophan hydroxylase. 25 of 35 What then acts on 5 hydroxytryptophan Aromatic amino acid decarboxylase AADC. this makes 5-hydroxytryptamine. 26 of 35 How is 5-HT broken down by MAOIa, into 5-HIAA 27 of 35 How is 5-HT transported back into the terminal SERT 28 of 35 How many Serotonin receptors are there 11, 1a-7 29 of 35 Which one is the odd one out 5HT-3, it's a ligand gated cation channel, not a GPCR 30 of 35 What are 5ht-1 coupled to Gi/go decrease camp 31 of 35 what are 5ht-2 coupled to gq/g11 ip3 increase, ca2 increase 32 of 35 two antagonists at the 5ht3 receptor. ondansetron, tropisetron, used as antiemetics and anxiolytics. 33 of 35 agonist at the 1d recetpor Sumatriptan - used for migraine 34 of 35 Fenfluramine Was used as an anti obesity drug, it increase 5ht release to promote fullness. 35 of 35
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