Molecules involved in the mechanism of NSAIDs 0.0 / 5 ? OtherPharmacyUniversityNone Created by: CourteneyCaleyCreated on: 21-12-20 02:20 COX-1 Produces prostanoids involved with homeostatic regulation (housekeeping roles) 1 of 9 COX-2 An inducible enzyme that can only be expressed in low levels, it is expressed more during inflammation. 2 of 9 PGD2 Vasodilator and inhibits platelet aggregation 3 of 9 PGE2 Causes uterine smooth muscle contraction, vasodilation, inhibition of gastric acid secretion, increased gastric mucus secretion and is hyperalgesic. 4 of 9 PGF2-Alpha Causes bronchoconstriction and uterine contractions. 5 of 9 TxA2 Vasoconstrictor and thrombotic. 6 of 9 PGI2 Vasodilator, hyperalgesic, inhibits platelet aggregation 7 of 9 LTB4 o Chemotaxin 8 of 9 LTC4 Bronchoconstriction, increase vascular permeability. 9 of 9
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