Microbiology lecture 9 4.0 / 5 based on 1 rating ? BiologyHost-bacterial interactionsUniversityNone Created by: willmiddlehamCreated on: 03-04-15 16:53 What is the secretion in the assembly of a fibril pilus? Via the Sec machine 1 of 19 What is the chaperone in the assembly of a fibril pilus? Periplasmic space 2 of 19 What is the usher in the assembly of a fibril pilus? outer membrane 3 of 19 What is the pilus in the assembly of a fibril pilus? fimbrillin/FimA 4 of 19 What is the adhesion in the assembly of a fibril pilus? FimH - lectin like proteins bind sugars 5 of 19 What are the two methods of protein secretion? Unfolded (polypeptides), folded (proteins) 6 of 19 What method is unfolded protein secretion? SEC - majority of secretion pathways, facilitate insertion of proteins into inner membrane 7 of 19 What method is folded protein secretion? TAT 8 of 19 How is protein secretion achieved in Gram -ve bacteria? Inner membrane --> SEC, Outer membrane --> specific system eg. fimbriae 9 of 19 Pathogenicity = Qualitative 10 of 19 Virulence = Quantitative 11 of 19 What are exotoxins encoded on? Plasmid or bacteriophage genomes 12 of 19 What do cytolytic exotoxins do? Lead to cell lysis 13 of 19 What do AB exotoxins do? B binds specific cell receptors --> B facilitates uptake of A --> A inhibits cellular process or damages cell 14 of 19 What do superantigens do? Over stimulate the immune system 15 of 19 What do enterotoxins do? Specific group that acts on small intestine 16 of 19 What do neurotoxins do? Often AB toxins that target nerve cells 17 of 19 What is toxicity? The ability to cause damage by means of a performed toxin. Infect 1 site and then damage another by releasing toxin 18 of 19 What is immunogenicity? Ability to provoke an immune response 19 of 19
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