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6. What is the role of an MHC molecule
- To activate inflammation
- To present processed antigen epitopes to T cells
- To attract cytokines to an infected area
- To signal inflammation
7. Which MHC molecule presents exogenous peptides?
- Both
- MHC 2 molecules
- MHC 1 molecules
- Neither
8. How can an MHC 2 be differentiated from MHC 1?
- MHC 2 molecules have 2 alpha and 2 beta chains, MHC 1 have 3 beta and 1 alpha
- MHC 2 molecules have 2 alpha and 2 beta chains, MHC 1 have 3 alpha and 1 beta
- MHC 1 molecules have 2 alpha and 2 beta chains, MHC 2 have 3 alpha and 1 beta
- You can't differentiate them
9. What is the role of CD4 and CD8 co-receptors?
- To activate necrosis in infected cells
- To increase the sensitivity of T cells by 100x
- To regulate the T cell response
- To stop TCR-MHC bonding
10. MHC 2 molecules are found on...
- Immune cells
- Infected cells
- Body cells
- Tumours
11. The interaction between TCRs and peptides can be described as...
- Un-specific
- Degenerate
- Deleterious
- Degenerative
12. What molecules are required for endogenous MHC1 processing
- lysosomes and the endoplasmic reticulum
- proteasome, ubiquitin, golgi body and TAAP
- proteasome, ubiquitin, endoplasmic reticulum, TAAP
- the golgi body and catalase
13. How to T cells bind to the peptides presented by MHCs?
- The T cell receptor is complementary to anchor residues on the peptide.
- With hydrogen bonds
- Hydrophobic and hydrophilic interactions
- All of the above
14. Which MHC molecule presents endogenous peptides?
- Neither
- MHC 2 molecules
- MHC 1 molecules
- Both
15. What cells can MHC molecules be found on?
- Both T and B cells
- B cells
- Antigen presenting cells (APCs)
- T cells
16. Peptides are promiscuous, which means...
- They can bind to multiple different MHC molecules
- They change shape and structure often
- They remain the same shape
- They can only bind to one MHC molecule shape
17. Why are the genes for MHCs the most polymorphous?
- It provides a survival advantage for the whole population during mass infections
- We aren't sure
- There is no reason for this
- It has implications for medicine
18. Where are the areas of highest variability found on an MHC molecule?
- Within the peptide binding groove
- There is no variation in MHC molecules
- On the tips
- On the outside of the groove
19. The genes HLA-DP, HLA-DQ (and HLA-DR) code for...
- T cell receptors
- Both MHC 1 and 2 molecules
- MHC 2 molecules
- MHC 1 molecules
20. CD8 co-receptors on CD8 cells recognise...
- MHC1 molecules
- Both MH1 and 2
- MHC2 molecules
- B cells