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6. What is the role of an MHC molecule

  • To activate inflammation
  • To present processed antigen epitopes to T cells
  • To attract cytokines to an infected area
  • To signal inflammation

7. Which MHC molecule presents exogenous peptides?

  • Both
  • MHC 2 molecules
  • MHC 1 molecules
  • Neither

8. How can an MHC 2 be differentiated from MHC 1?

  • MHC 2 molecules have 2 alpha and 2 beta chains, MHC 1 have 3 beta and 1 alpha
  • MHC 2 molecules have 2 alpha and 2 beta chains, MHC 1 have 3 alpha and 1 beta
  • MHC 1 molecules have 2 alpha and 2 beta chains, MHC 2 have 3 alpha and 1 beta
  • You can't differentiate them

9. What is the role of CD4 and CD8 co-receptors?

  • To activate necrosis in infected cells
  • To increase the sensitivity of T cells by 100x
  • To regulate the T cell response
  • To stop TCR-MHC bonding

10. MHC 2 molecules are found on...

  • Immune cells
  • Infected cells
  • Body cells
  • Tumours

11. The interaction between TCRs and peptides can be described as...

  • Un-specific
  • Degenerate
  • Deleterious
  • Degenerative

12. What molecules are required for endogenous MHC1 processing

  • lysosomes and the endoplasmic reticulum
  • proteasome, ubiquitin, golgi body and TAAP
  • proteasome, ubiquitin, endoplasmic reticulum, TAAP
  • the golgi body and catalase

13. How to T cells bind to the peptides presented by MHCs?

  • The T cell receptor is complementary to anchor residues on the peptide.
  • With hydrogen bonds
  • Hydrophobic and hydrophilic interactions
  • All of the above

14. Which MHC molecule presents endogenous peptides?

  • Neither
  • MHC 2 molecules
  • MHC 1 molecules
  • Both

15. What cells can MHC molecules be found on?

  • Both T and B cells
  • B cells
  • Antigen presenting cells (APCs)
  • T cells

16. Peptides are promiscuous, which means...

  • They can bind to multiple different MHC molecules
  • They change shape and structure often
  • They remain the same shape
  • They can only bind to one MHC molecule shape

17. Why are the genes for MHCs the most polymorphous?

  • It provides a survival advantage for the whole population during mass infections
  • We aren't sure
  • There is no reason for this
  • It has implications for medicine

18. Where are the areas of highest variability found on an MHC molecule?

  • Within the peptide binding groove
  • There is no variation in MHC molecules
  • On the tips
  • On the outside of the groove

19. The genes HLA-DP, HLA-DQ (and HLA-DR) code for...

  • T cell receptors
  • Both MHC 1 and 2 molecules
  • MHC 2 molecules
  • MHC 1 molecules

20. CD8 co-receptors on CD8 cells recognise...

  • MHC1 molecules
  • Both MH1 and 2
  • MHC2 molecules
  • B cells