MHC

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What must happen for an appropriate response
Lymphocytes must recognise antigen, stimulated to divide and differentiate
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What mediates antigen recognition on B and T cells?
B cells mediated by surface immunoglobulin. T cells mediated by T cell receptor
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What is MHC
Pathogen derived peptides delivered to and presented at cell surface by specialized glycoprotein
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What are the two MHC families and what are the members of each?
Class I: HLA-A, HLA-B, HLA-C. Class II: HLA-DP, HLA-DQ, HLA-DR
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Wheres each class expressed?
Class I= on all nucleated cells including leucocytess. Class II= only on leucocytes which present antigen to T cells like monocytes
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Functions of Class I and Class II MHC proteins
MHC present antigenic peptides to T cells. MHC class I present peptides to Tc cells. MHC class II present peptides to TH cells
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antigen recognition on B cells is mediated by what
by surface immunoglobulin
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antigen recognition on T cells is mediated by what
TCR
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What kind of antigens do T cells recognise
antigens that are expressed on cell surfaces
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the antigens that are expressed on cell surfaces are derived from what? and from where
derived from pathogens that replicate within host cells e.g. viruses or intracellular bacteria. these antigens may come from pathogens or their products that have been endocytosed from the extracellular fluid
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on what chromosome are MHC proteins encoded on
encoded in large cluster of genes on chromosome 6
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what do T cells recognise
combination of MHC molecule and small peptide fragment of antigen
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the protein domains nearest the membrane resemble what
immunoglobulin domain
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the domains furtherst away from the membrane fold together to create what
a long groove- antigenic peptide binds in this groove
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how does MHC class II differ from MHC Class I
Peptide binding cleft is more open
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by what What are peptides anchored into the groove formed by upper two domains ?
by H bonds
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MHC Class I and MHC Class II present peptides to what T cells
MHC Class I= Tc MHC Class II=T helper cells
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Other cards in this set

Card 2

Front

What mediates antigen recognition on B and T cells?

Back

B cells mediated by surface immunoglobulin. T cells mediated by T cell receptor

Card 3

Front

What is MHC

Back

Preview of the front of card 3

Card 4

Front

What are the two MHC families and what are the members of each?

Back

Preview of the front of card 4

Card 5

Front

Wheres each class expressed?

Back

Preview of the front of card 5
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