Metals in biology

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What aa can interact with metal ions?
His (N) Glu and ASP (O) Cys(S)
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How can you predict what metal ion is attached?
By seeing the gaps between the bonds, and measuring them
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Magnesium's role
cofactor complex with ATP and in enzymes.
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Ca's role
regulator in cells, muscle contraction
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NA and K
pump.
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Zinc
no clinical test to show but involved in basically all processes. 24 importers and exporters of zinc so much be important. Insulin stored in zinc complex in liver. Enzyme for pH regulation
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Molybdenum
cofactor peterin. 4 enzymes in humans that need it. catalyses nitrogen reactions in cells to form NH3 ammonia without high temps
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Cobalt
vitamin b12, 2 enzymes in metabolism,
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nickle
not found in humans but 9nickel-enzymes known and cofactors
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Iron
haem group, needed for hormone hepicidin which controls fe transport from cells. nitric acid cycle, conc needs to be tightly regulated.
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What is transferrin?
Molecule that binds to 2 Fe3+ ions and transports it in blood taking it to bone marrow to make RBC.
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What is ferritin 3+
the storage form of iron, inside a mineral core. when needed it is transferred to Fe2+/
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Card 2

Front

How can you predict what metal ion is attached?

Back

By seeing the gaps between the bonds, and measuring them

Card 3

Front

Magnesium's role

Back

Preview of the front of card 3

Card 4

Front

Ca's role

Back

Preview of the front of card 4

Card 5

Front

NA and K

Back

Preview of the front of card 5
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