Meningococcal vaccines 0.0 / 5 ? BiologyVGTUniversityNone Created by: Moyo OlukogaCreated on: 10-04-14 19:10 Which vaccine has a poor response in children? Capsular polysaccharide (CPS) vaccine 1 of 17 Which vaccine has a poor immune memory CPS vaccine 2 of 17 Which vaccine does not induce T-cell immunity? CPS 3 of 17 The tetravalent vaccine induces a response to which meningococcal serotypes? A and W-135 4 of 17 CPS vaccine largely elicit what type of response? IgM and IgG2 5 of 17 Which vaccine is safer, CPS or conjugated CPS? Conjugated CPS 6 of 17 Conjugated CPS vaccine is not immunogenic in children, true or false? False 7 of 17 Which vaccine doesn't require boosters? Conjugated CPS 8 of 17 Conjugated CPS vaccine reduces _____ carriage and _____ through ____ immunity nasopharyngeal, transmission, herd 9 of 17 What carriers are used in meningococcal group C vaccines? Detoxified diphtheria or tetanus toxoid 10 of 17 What has meningococcal group C vaccine reduced? Meningococcal deaths, clinical cases, asymptomatic carriage, non-vaccinated case (herd immunity) 11 of 17 What type A and W-135 vaccines have been developed? Men A/C bivalent vaccine, MenA/C/Y/W-135 tetravalent, MenAfriVac 12 of 17 What are potential vaccine targets for group B meningococcal? Outer membrane vesicles (OMV), oute membrane proteins (OMP) and lipooligosaccharides (LOS) 13 of 17 What are the limitations of these targets? OMP- not cross protective, OMV- strain specific, 14 of 17 Highlight the use of PorA and it's limitations Used in Norway and Cuba, 50-80% effective however has a short immune response and no protection for the under fours 15 of 17 What are the four components in the 4CMenB vaccine? Factor H, Neisseria heparin binding antigen, Neisserial adhesin A, MenZB vaccine 16 of 17 What is the latest on 4CMenB Last month, the JCVI recommended routine use of 4CMenB to the UK government 17 of 17
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