Meningococcal vaccines

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Which vaccine has a poor response in children?
Capsular polysaccharide (CPS) vaccine
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Which vaccine has a poor immune memory
CPS vaccine
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Which vaccine does not induce T-cell immunity?
CPS
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The tetravalent vaccine induces a response to which meningococcal serotypes?
A and W-135
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CPS vaccine largely elicit what type of response?
IgM and IgG2
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Which vaccine is safer, CPS or conjugated CPS?
Conjugated CPS
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Conjugated CPS vaccine is not immunogenic in children, true or false?
False
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Which vaccine doesn't require boosters?
Conjugated CPS
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Conjugated CPS vaccine reduces _____ carriage and _____ through ____ immunity
nasopharyngeal, transmission, herd
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What carriers are used in meningococcal group C vaccines?
Detoxified diphtheria or tetanus toxoid
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What has meningococcal group C vaccine reduced?
Meningococcal deaths, clinical cases, asymptomatic carriage, non-vaccinated case (herd immunity)
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What type A and W-135 vaccines have been developed?
Men A/C bivalent vaccine, MenA/C/Y/W-135 tetravalent, MenAfriVac
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What are potential vaccine targets for group B meningococcal?
Outer membrane vesicles (OMV), oute membrane proteins (OMP) and lipooligosaccharides (LOS)
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What are the limitations of these targets?
OMP- not cross protective, OMV- strain specific,
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Highlight the use of PorA and it's limitations
Used in Norway and Cuba, 50-80% effective however has a short immune response and no protection for the under fours
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What are the four components in the 4CMenB vaccine?
Factor H, Neisseria heparin binding antigen, Neisserial adhesin A, MenZB vaccine
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What is the latest on 4CMenB
Last month, the JCVI recommended routine use of 4CMenB to the UK government
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Card 2

Front

Which vaccine has a poor immune memory

Back

CPS vaccine

Card 3

Front

Which vaccine does not induce T-cell immunity?

Back

Preview of the front of card 3

Card 4

Front

The tetravalent vaccine induces a response to which meningococcal serotypes?

Back

Preview of the front of card 4

Card 5

Front

CPS vaccine largely elicit what type of response?

Back

Preview of the front of card 5
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