Link Reaction and Krebs Cycle

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  • Created by: Beth
  • Created on: 22-01-14 13:25
Link Reaction
Converts pyruvate to acetate. NAD is reduced
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Pyruvate dehrydrogenase
Removes hydrogen atoms from the pyruvate
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Pyruvate hydrogenase
Removes the carboxyl group, which becomes Carbon Dioxide, from pyruvate
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Coenzyme NAD
Accepts the hydrogen atoms
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Coenzyme A (CoA)
Accepts acetate, to become acetyl coenzyme A. CoA carries acetate to Krebs cycle
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2Pyruvate + 2NAD + 2CoA =
2CO2 + 2Reduced NAD + 2Acetyl CoA
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Krebs Cycle
Oxidises acetate to carbon dioxide. NAD and FAD are reduced. ATP is made by Substrate-Level Phosphorylation. Takes place in the Mitoxhondrial Matrix.
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The acetate from Acetyle Coenzyme AQ joins with a 4-carbon compound, oxaloacetate, to form 6-carbon compound citric acid. Coenzyme A is released and becomes available to accept more acetate.
Stage 1
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Citrate is decarboxylated (one molecule of carbon dioxide is removed) and dehydrogenated (a pair of hydrogen atoms is removed) to form a 5-carbon compound. The pair of hydrogen atoms is accepted by a molecule of NAD, which becomes reduced.
Stage 2
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The 5-Carbon compound is decarboxylated and dehydrogenated to form a 4-carbon comound and another molecule of reduced NAD.
Stage 3
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The 4-carbon compound is canged into another 4-carbon compound. During this reaction a molecule of ADP is phosphorylated to produce a molecule of ATP. This is substrate-level phosphorylation.
Stage 4
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The second 4-carbon compound is changed into another 4-carbon compound. A pair of hydrogen atoms is removed and accepted by the coenzyme FAD, which is reduced.
Stage 5
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The third 4-carbon compound is further dehydrogenated and regenerates oxaloacetate. Another molecule of NAD is reduced.
Stage 6
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Reduced NAD
Link Reaction: 2 Krebs Cycle: 6
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Reduced FAD
Link Reaction: 0 Krebs Cycle: 2
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Carbon dioxide
Link Reaction: 2 Krebs Cycle: 4
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ATP
Link Reaction: 0 Krebs Cycle: 2
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For each cycle, one acetate molecule produces...
1 molecule of pyruvate (2 cycles = 1 glucose)
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Other cards in this set

Card 2

Front

Removes hydrogen atoms from the pyruvate

Back

Pyruvate dehrydrogenase

Card 3

Front

Removes the carboxyl group, which becomes Carbon Dioxide, from pyruvate

Back

Preview of the back of card 3

Card 4

Front

Accepts the hydrogen atoms

Back

Preview of the back of card 4

Card 5

Front

Accepts acetate, to become acetyl coenzyme A. CoA carries acetate to Krebs cycle

Back

Preview of the back of card 5
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