Lecture 12 Cell development and genetics KERTMORGAN

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What is a growth factor
Extracellular protein that promotes growth, proliferation, differentiation or survival of cells
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Do they acti over long or short distances
Short - they act locally
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How do GFs bring about change
cause changes in target cell biology via binding to specific receptors, which often lead to changes in gene expression over a period of hours, or may lead to very rapid alterations in the cell cytoskeleton.
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What are the 4 main modes of communication?
Endocrine, Paracrine, neuronal, contact dependent
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What are the 4 general ways cells respond to GFs
1 Survive, 2 grow and divide, 3 Differentiate, 4 Die
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What are the more specific ways GF function in vivo
1. early development, 2 Tissue differentiation, 3 wound healing, 4, immune responses, 5 Stromal mediators of sex and other hormone
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What are the more specific ways GF functions in vitro
1. Proliferation 2. Differentiation 3. Chemo-attraction 4. Chemo-kinesis 5. Trophic action
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What is trophic actino
the stimulation of cell reproduction and enlargement by nurturing and causing growth
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What is chem-kinesis
The response of a cell to a chemical that causes the cell to make some kind of change in its movement by speeding it up, slowing it down or changing its direction.
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What is the slow response to GFs
Extracellular signal binds to receptor this signal is carried to DNA changing gene expression, resulting in altered cell behaviour
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what is the fast response to GF
Extracellular signal binds to receptor THIS ACTIVATES INTRACELLULAR SIGNALLING CASCADE this alters protein function and thereroe ctoplasmic machinery changin cell behaviour
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After GF receptor is activated what are 3 possible mechanisms of action
1. altered cytoskeleton 2 activated ser/thr kinases 3 activation of translation factors
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Do they acti over long or short distances

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Short - they act locally

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How do GFs bring about change

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What are the 4 main modes of communication?

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What are the 4 general ways cells respond to GFs

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