LD and linkage definitions

  • Created by: amh4
  • Created on: 20-02-17 14:17
Define association
Genetic association is the association between disease or trait and a genotype or allele of a known marker using population or family data.
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Define Linkage
Linkage describes for two (or more) markers in close enough proximity to one another on the same chromosome to have a recombination frequency of less than 50% (θ
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HWE
the equilibrium state of allele frequencies at a single locus in a randomly mating diploid population
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HWE assumptions
No genetic drift, large population, random mating, males and females share allele frequencies, no mutation or migration, no natural selection for genotypes
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Factors that influence the rate of LD breakdown
Recombination, mutation rate, population size, natural selection, genetic drift, founder effect
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Recombination hotspots
Low levels of LD, frequent recombination
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LD hotspots
Rare recombination - alleles are associated in the population
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Polymorphism
Common genetically determined variation, MAF >0.01
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Other cards in this set

Card 2

Front

Define Linkage

Back

Linkage describes for two (or more) markers in close enough proximity to one another on the same chromosome to have a recombination frequency of less than 50% (θ

Card 3

Front

HWE

Back

Preview of the front of card 3

Card 4

Front

HWE assumptions

Back

Preview of the front of card 4

Card 5

Front

Factors that influence the rate of LD breakdown

Back

Preview of the front of card 5
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