Kidney Embryogenesis

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  • Created by: Sarah
  • Created on: 20-04-18 09:39
what cell events happen in the kidney that do not happen in the eye?
build a tube from a bud, branching morphogenesis, connect tubes, attract blood capillaries
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what are the attempts are making the kidney called?
pronephros, mesonephros
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what does the definitive kidney form from?
metanephros
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how does the definitive kidney arise?
result of reciprocal interactions between the ureteric duct and the metanephric mesenchyme
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what is the small outpocketing of intermediate mesoderm called?
the ureteric bud
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what does the metanephric mesenchype form?
nephrons
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what does the ureteric bud induce in the nephrogenic mesenchyme?
Mesenchymal to epithelial transition condenses
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what does this M to E cause?
nephronic mesenchyme --> renal epithelium --> renal vesicles
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how do you go from nephrogenic mesenchyme to a renal vesicle?
mesenchyme to epithelium compact to form a vesicle
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what is the order from nephronic (metaneric) mesenchyme?
nephrogenic mesenchyme --> renal vesicle --> S shaped body --> nephron
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what happens to the distal end of the nephron?
they attract endothelial capillaries (glomerulus)
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what happens to the proximal end of the nephron?
they fuse with the bud (future collecting duct?)
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what makes a renal vesicle turn into an S shaped body?
proliferation
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what is the word that the s shaped body has different properties at the distal and proximal ends (bcos of siganlling pathways)?
polarised
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what happens so the ureteric bud become a flattened shape?
proliferation and outgrowth of bud tip cells but then arrests proliferation of leading edge tip cells but lateral edge tip cells continue to proliferate
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what does the continued proliferation of lateral tip cells form?
formation of a cleft and 2 tips that will form 2 branches/ (buds?)
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what is branching morphogenesis governed by?
signals
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where do the signals for branching morphogenesis of the ureteric bud come from?
metanephric mesenchyme
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what will help you remember that the ureteric bud undergoes branching morphogenesis?
it is the part of the tree it needs to branch to give the major calyces, minor calyces and ureter
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what signal comes the metanephric mesenchyme to induce branching morphogensis of the ureteric bud?
GDNF- glia derived neurotrophic factor
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what is the receptor GDNF binds to on the ureteric bud?
ret rec- a recptor TK
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what does GDNF promote?
proliferation, migration, outgrowth and survival
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Card 2

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what are the attempts are making the kidney called?

Back

pronephros, mesonephros

Card 3

Front

what does the definitive kidney form from?

Back

Preview of the front of card 3

Card 4

Front

how does the definitive kidney arise?

Back

Preview of the front of card 4

Card 5

Front

what is the small outpocketing of intermediate mesoderm called?

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