how do you go from nephrogenic mesenchyme to a renal vesicle?
mesenchyme to epithelium compact to form a vesicle
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what is the order from nephronic (metaneric) mesenchyme?
nephrogenic mesenchyme --> renal vesicle --> S shaped body --> nephron
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what happens to the distal end of the nephron?
they attract endothelial capillaries (glomerulus)
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what happens to the proximal end of the nephron?
they fuse with the bud (future collecting duct?)
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what makes a renal vesicle turn into an S shaped body?
proliferation
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what is the word that the s shaped body has different properties at the distal and proximal ends (bcos of siganlling pathways)?
polarised
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what happens so the ureteric bud become a flattened shape?
proliferation and outgrowth of bud tip cells but then arrests proliferation of leading edge tip cells but lateral edge tip cells continue to proliferate
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what does the continued proliferation of lateral tip cells form?
formation of a cleft and 2 tips that will form 2 branches/ (buds?)
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what is branching morphogenesis governed by?
signals
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where do the signals for branching morphogenesis of the ureteric bud come from?
metanephric mesenchyme
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what will help you remember that the ureteric bud undergoes branching morphogenesis?
it is the part of the tree it needs to branch to give the major calyces, minor calyces and ureter
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what signal comes the metanephric mesenchyme to induce branching morphogensis of the ureteric bud?
GDNF- glia derived neurotrophic factor
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what is the receptor GDNF binds to on the ureteric bud?
ret rec- a recptor TK
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what does GDNF promote?
proliferation, migration, outgrowth and survival
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Other cards in this set
Card 2
Front
what are the attempts are making the kidney called?
Back
pronephros, mesonephros
Card 3
Front
what does the definitive kidney form from?
Back
Card 4
Front
how does the definitive kidney arise?
Back
Card 5
Front
what is the small outpocketing of intermediate mesoderm called?
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