kidney 5

What is the normal range of plasma osmolality?
285-295 mosmol/kg
1 of 10
Define hyperkalemia
Plasma conc of potassium higher than 5.5mM
2 of 10
Where are ROMK channels expressed
principal cells of the collecting duct
3 of 10
explain extrinsic control fo GFR
maintains systemic blood pressure. SNS vasoconstriction of AA. mesangial cells contract. conserve sodium and water. increase BP.
4 of 10
explain intrinsic control of GFR
protects renal capillaries from hypertensive damage, auto-regulation of aa constriction. myogenic response in renal sm, if stretch vaso constrict. Juxtaglomerular apparatus vasoconstriction and renin release
5 of 10
Tubuloglomerular feedback-
as increase in NaCl to mascula densa ATP-ADP increases adenosine, causes ca conc to increase-vasoconstriction of AA. also JG cells decrease renin release
6 of 10
what does angiotensin 2 do?
stimulates PT Na reabsorption by binding to AT1 receptors, stimulates ADH release, aldosterone secretion (increase Na reabsorption in CD and DCT), thirst, vasoconstriction of small arterioles
7 of 10
Tell me about aldosterone
secreted by zona glomerulosa in adrenal cortex (also caused by increased K+ conc) stimulates principal cells in CD to produce Na/K pumps and Na channels. water follows Na+
8 of 10
natriuretic peptides
are released when the heart is stretched. A type-from atrial myocardium and B type -ventricular myocardium DNP
9 of 10
what do natriuretics do?
acts on CD, cells inhibit Na+ entry through ENaC, inhibit renin release, with dopamine inhibit Na/K pump in PT. promotes dopamine entry into PT through OCT (organic cation transporter)
10 of 10

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Card 2

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Define hyperkalemia

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Plasma conc of potassium higher than 5.5mM

Card 3

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Where are ROMK channels expressed

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Card 4

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explain extrinsic control fo GFR

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Card 5

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explain intrinsic control of GFR

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