Immunology T1

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  • Created by: Sjabon
  • Created on: 17-02-15 15:37
Why is the immune system so important to us?
1)day to day protection from disease 2)responds to tumours and cancers 3)responsible for hypersensitivity and autoimmune disease
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How specific are TCR and BCR?
Can recognise sequences that are 10 AA's long, very specific and can recognise a vast amount of antigen
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What do macrophages release upon interaction with pathogen?
chemokines and cytokines
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What do chemokines and cytokines do?
Chemokines: are attractants and attract other WBC to the area. Cytokines: changes the behaviour of cells.
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Name 6 PRR's
TLR-2 (gram positive); TLR-4 (gram negative); scavenger receptor; glycan receptor; mannose receptors; LPS receptors (CD14); mannose receptor
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What are the 2 progenitors called?
common lymphoid progenitor and the common myeloid progentior
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name the primary lymphoid organs
thymus and bone marrow
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what is pinocytosis
When the dendritic cells use their dendrites to 'taste' the area around them for pathogens
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General overview of how antigen is present to T cells?
binding of small linear fragments of antigen which are held on MHC receptors
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True or false? T cells help activate B cells into effector b cells? and how?
True. so the b cell will engulf the antigen and then it will express the antigen onto the cell surface - t cell will bind and then activate the b cells
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how many transmembrane domains do class 1 and 2 MHC's have?
class 1: 1, class 2: 2
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What is the difference between the antigen of class 1 and class 2?
class 1 antigen is intracellular and class 2 is extracellular
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which cells binds to MHC class 1 and which one onto MHC class 2?
class 1: cytotoxic T cells (to kill viruses so they induce apoptosis on those cells). class 2: t helper cells
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which cells binds to MHC class 1 and which one onto MHC class 2?
class 1: cytotoxic T cells (to kill viruses so they induce apoptosis on those cells). class 2: t helper cells
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Card 2

Front

How specific are TCR and BCR?

Back

Can recognise sequences that are 10 AA's long, very specific and can recognise a vast amount of antigen

Card 3

Front

What do macrophages release upon interaction with pathogen?

Back

Preview of the front of card 3

Card 4

Front

What do chemokines and cytokines do?

Back

Preview of the front of card 4

Card 5

Front

Name 6 PRR's

Back

Preview of the front of card 5
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