Name the properties of lymphocytes in adaptive immunity?
5 x10^11 in total, 20% B-cells 80% T cells, 49% in tissues 49% in lymph nodes + organs, only inactive cells circulate
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Name the 4 principles of clonal selection
1) Each lymphocyte has a single type of receptor with unique specificity 2) activation is achieved via interaction between foreign molecule and LR 3) differentiated effector cells same specificity as parental 4) LR specific for self mol. = deleted
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Where do receptors bind?
Epitopes - BCR = 3D, TCR = linear peptide
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Describe the Peyer's patches (GALT)
Covered by epithelial layer containing M cells, M cells have membrane ruffles
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Name 3 APC
1) Dendritic 2) Macrophage 3) B lymphocyte
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How do TCR bind to MHC molecule (epitopes)
1) Antigen broken down inti peptide fragments (epitope buried) 2) epitope peptide binds to self molecule (MHC) 3) TCR binds to a complex of MHC & epitope peptide
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Name the 3 ways in which antibodies produced by B cells protect against extraceullar pathogen?
1) Neutralization (ingestion by macrophage) 2) Opsonization (ingestion by macrophage) 3) Complement activation (lysis and ingestion)
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What T cells bind to which class of MHC molecules?
MHC Class 1 - CD8 (Tc cells) MHC Class II - CD4 (Th cells)
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Why is the immune system important?
1)day to day protection from disease 2)responds to tumours and cancers 3) responsible for hypersensitivity and autoimmune disease
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Other cards in this set
Card 2
Front
How does adaptive immunity differ from innate immunity?
Back
1) Sepcific recognition molecules BCR, TCR 2) Generate immunological memory 3) TCR + BCR recognise all available antigens (not self)
Card 3
Front
How is the inflammatory response induced?
Back
Card 4
Front
What provides initial discrimination between self & non-self?
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