Immunology of Allergy - BM5 RCR1

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1. Activated Th2 cells secrete cytokines. What are the main roles of cytokines?

  • To induce apoptosis in epithelial cells
  • To regulate inflammation, proliferation and differentiation of inflammatory cells
  • To bind to bacterial/viral toxins and destory them
  • To bind to antigens and destroy them
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2. Identify the correct actions of histamine from the list below.

  • Secretes IL-4 & IL-13 in order to regulate the inflammatory response
  • Regulates IL-4 & IL-13 in order to then regulate the inflammatory response
  • Opens capillary bed & therefore increases blood flow to the affected area
  • Secretes proteolytic enzymes and TNF-alpha

3. CysLT and LTB-4 are very potent bronchoconstrictors. From what are they derived?

  • Thromboxanes
  • Leukotrienes
  • Prostaglandins
  • Cytokines

4. Once mast cells are activated, how long does it take for them to release their pre-formed mediators?

  • 0-1 minutes
  • 2-5 minutes
  • 5-10 minutes
  • 1-2 minutes

5. Which of the following provides the best definition of allergy?

  • An abnormal nervous response to a common chemical agent
  • An abnormal immune response to a common environmental agent
  • A normal immune response to an obscure environmental agent
  • A normal nervous response to an obscure chemical agent
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