Immunology of Allergy - BM5 RCR1

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1. In order to arm the Th2 cell during activation, a co-stimulatory signal is required. Between which molecules does this occur? (First molecule(s) = on dendritic cell, Second molecule(s) = on Th2 cell)

  • CD28 & CD40/CD46
  • CD28 & CD80/CD86
  • CD80/CD86 & CD28
  • CD40/CD46 & CD28
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2. When an allergen comes into contact with an allergic airway, what happens to the FEV1?

  • Sharp decrease
  • Sharp increase
  • Gradual decrease
  • Gradual increase

3. Activated Th2 cells secrete cytokines. What are the main roles of cytokines?

  • To regulate inflammation, proliferation and differentiation of inflammatory cells
  • To bind to antigens and destroy them
  • To bind to bacterial/viral toxins and destory them
  • To induce apoptosis in epithelial cells

4. Which of the following are changes seen in the asthmatic lung?

  • Thickening of the lamina reticularis with collagen
  • Thinning of the lamina reticularis
  • Thickening of the lamina propria with elastin
  • Thickening of the basal lamina with smooth muscle

5. Identify the correct actions of histamine from the list below.

  • Opens capillary bed & therefore increases blood flow to the affected area
  • Regulates IL-4 & IL-13 in order to then regulate the inflammatory response
  • Secretes proteolytic enzymes and TNF-alpha
  • Secretes IL-4 & IL-13 in order to regulate the inflammatory response


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