Proinflammatory, released by macrophages and dendritic cells.
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What about IL2?
Stimulate lymphocyte proliferation, released by T cells
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What about IL4?
Class switches B cells to IgE production, released by Th2 cells.
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What about IL10?
Stimulates B cells and supresses Th1 cells, released by monocytes, Th2 cells and Treg cells.
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What do Th1 cells do?
Stimulate microbial killing by macrophages. Activate Tc cells.
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What about IL12?
Promotes Th1 differentiation, released by macrophages and dendritic cells.
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What about IL17?
Proinflammatory, released by Th17.
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What about cytokines in general?
ALL CYTOKINES HAVE MULTIPLE ROLES
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What are colony stimulating factors? Name the tree main CSFs.
Used to differentiate cells. GM-CSF for myeloid cells, M-CSF for monocytes, G-CSF for grnulocytes.
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What do inteferons do?
Intefere with virus replication
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What are the differences between IFN type I and IFN type II?
Type I are produced by all nucleated cells and are IFNalpha and IFNbeta. Type II is produced by NK cells, T cells, IFNgamma. Regulates Th1 cell production and macrophage activation.
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What is TNF?
Macrophage activation, induction of endothelial cell and endothelial cell adhesion molecules. Stimulates other cytokines to be produced.
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What are Chemokines?
Chemotactic activity.
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What cytokines are dangerous in excess?
IL4 and IL5 in allergy. TNF can cause death!!
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What cytokines are used therpeutically?
IL2 are used in renal cell carcinoma. IFNalpha used in Hep C treatment. CSF treatment of bone marrow failure/ost transplant.
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