immunology 3 ig structure and function

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1. Where are antibodies present?
1. Plasma, tissues, secretions and lymphatics
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2. What are the 5 classes of immunoglobulins?
2. IgG, IgM, IgD, IgE
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3. What is the role of FAB, hinge, fc?
3. FAB: to bind antigens- recognition function, FC: effector side of the antibody. It has a clearance mechanism, interaction of Fc with effector molecules. Hinge for flexibility
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4. What are the 2 types of light chains? And what are the 2 globular domains formed
4. Lambda, kappa. The globular domains: variable constant and constant light
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5. What does the. Heavy chain determine?
5. Heavy chain determines class of antibody.
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6. What heavy chain forms the IgM,A,D,E,G?
6. IgM=U heavy chain, Alpha,gamma,E,y
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7. What is the antigen binding site made of?
7. 6 hypervariable regions (or CDR)- 3 in VH, 3 in VL
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8. Where is IgG most abundant, what shape does it have, what is its role? How many subclasses?
8. Most abundant Ig in plasma. It is y shaped, very efficient at triggering complement and phagocytosis via Fc receptors. Predominant antibody of 2 ry response.
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9. Where are IgM found? How many globular domains does it have
9. Only in plasma and secretions. It has 5 globular domains
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10. What is its role of IgM
10. Agglutinating particles, activate acomplement
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11. Where is the IgA found, how many subclasses does it have? What are its two forms? Describe serum and secretory IgA
11. In seromucous secretions: saliva, milk, colostrum, gut, tracheobronchial system, genito-urinary sysyem. 2, monomeric and dimeric. Serum- monomeric: IgA1 90% IgA2 10%. Secretory- dimeric. IgA1 40%, IgA2 60% +sc
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12. What is the IgE effector function?
12. Interacts with FcRI, high affinity receptor, expressed on mast cells and basophils, associated with allergic response, also important against parasitic infection
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13. Where is IgD found?
13. On surface of lymphocytes
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14. What are the 2 types of effector molecules
14. Fc receptors and complement
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15. What do FcalphaR bind?
15. IgA Fc
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16. What Fc receptors are present on neutrophils?
16. FcyRII, FcyRIIIB, FcalphaRI
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17. What does the antibody coated targets of FcR on immune cells can results in?
17. Phagocytosis, release of activated oxygen species and enzymes, release of inflammatory mediators (histamine), enhanced antigen presentation and clearance of immune complexes
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Other cards in this set

Card 2

Front

2. What are the 5 classes of immunoglobulins?

Back

2. IgG, IgM, IgD, IgE

Card 3

Front

3. What is the role of FAB, hinge, fc?

Back

Preview of the front of card 3

Card 4

Front

4. What are the 2 types of light chains? And what are the 2 globular domains formed

Back

Preview of the front of card 4

Card 5

Front

5. What does the. Heavy chain determine?

Back

Preview of the front of card 5
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