Immunology 1 0.0 / 5 ? Veterinary ScienceImmunologyUniversityNone Created by: leahhunter1506Created on: 10-05-17 11:37 Role of Macrophage Innate response- Induction of acute inflammation 1 of 10 Role of Neutrophil Extracellular killing of bacteria- Reactive Oxygen Pathway, producing O* radicals and OH- ions. Nitric Oxidase synthase- producing NO and Cl- ions. 2 of 10 Contents of Eosinophils Major Basic Protein, Eosinophil Cationic Protein, Eosinophil Perioxidase, Eosinophil derived neurotoxin 3 of 10 Role of MBP and ECP Major Basic Protein: Disrupts worm cuticle and kills epithelia. Eosinophil cationic protein: Ribonuclease, anti-viral. 4 of 10 Role of EPO and EDN Eosinophil Peroxidase: generates Cl-, Br- and OH- oxidation. Eosinophil derived neurotoxin: ribonuclease, anti viral. 5 of 10 Role of Eosinophil and Mast Cells Acts on parasites and extracellular organisms by rapidly secreting antimicrobial compounds into extracellular space 6 of 10 Role of NK cells Release preformed cytotoxic granules that kill cell. Recognise lack of MHC present on plasma membrane of a virus infected cell so kills it. 7 of 10 Difference between primary and second response Same levels of IgM, IgG is produced earlier and higher levels are made in the secondary response. 8 of 10 Role of Antibodies Neutralise Bacterial toxins, opsonise bacteria in extracellular space, activate complement with bacteria within the plasma. 9 of 10 Complement Biological cascade leading to the lysis of microbes and activation of secondary innate and adaptive immune response. 10 of 10
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