Histology of Bone - BM5 NLM1

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1. What is the main function of the inorganic minerals in the bone ECM?

  • Causes generation of Osteoclasts
  • Binds to and mineralises the Osteoid
  • Causes generation of Osteoblasts
  • Causes generation of Osteocytes
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2. What are Osteoclasts?

  • Large, motile, single nucleated cells of ECM origin
  • Large, motile, multinucleated cells of bone marrow origin
  • Large, immotile, multinucleated cells of ECM origin
  • Small, motile, multinucleated cells of ECM origin

3. Which of the following best describes immature/woven bone?

  • Strong, permanent bone with high mineral contents and organised lacing of collagen fibres. Forms the foetal skeleton.
  • Strong, permanent bone with high mineral contents and organised lacing of collagen fibres. Forms the adult skeleton.
  • Weak, temporary bone with low mineral contents and disorganised lacing of collagen fibres. Forms the foetal skeleton.
  • Weak, temporary bone with low mineral contents and disorganised lacing of collagen fibres. Forms the adult skeleton.

4. What makes up the majority of the inorganic minerals of the bone ECM (hint: aka Hydroxyapatite crystals)?

  • Magnesium nitrate complexes
  • Sodium fluoride complexes
  • Calcium phosphate complexes
  • Magnesium phosphate complexes

5. What do Osteoclasts secrete?

  • Collagen type II & elastin
  • Organic acids & proteolytic enzymes
  • Collagen type I & proteoglycans
  • PTH & fibrin

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