Hair follicle stem cell niche 0.0 / 5 ? BiologyRegenerative medicineUniversityAll boards Created by: DanielledarcyCreated on: 29-12-19 10:55 How does the hair follicle regenerate? Through phases of cyclic growth, regression and rest. 1 of 13 Where do stem cells in the hair follicle reside? Epithelial bulge 2 of 13 Where is the epithelial bulge located? At the base of the permanent portion of the hair follicle 3 of 13 How is hair growth initiated? By cues from the underlying dermal papilla 4 of 13 What does the dermal papilla do? Activates resident stem cells to give rise to transit amplifying cells 5 of 13 What does FGF5, EGF and TGF-b signalling promote in the HF stem cell niche? The transition from anagen to catagen 6 of 13 Which signalling molecules are released to maintain quiescence during the resting phase? BMP, TGF-b, FGF ligands and Wnt inhibitors 7 of 13 Quiescence of stem cells in the HF niche activates which molecules? Wnt and Shh 8 of 13 Which cell types are involved in the HF niche? Keratinocytes, arrector pili muscle, sensory nerves and adipocyte precursors 9 of 13 What is the role of keratinocytes in the HF niche? Establishing and maintaining melanocyte stem cells in the bulge 10 of 13 What is the role of the arrector pili muscle in the HF niche? Promotes muscle differentiation and attachment through integrin binding 11 of 13 What is the role of sensory nerves in the HF niche? Influences the molecular signature of epithelial cells in the upper bulge 12 of 13 What is the role of adipocyte precursors in the HF niche? Release PDGFa to stimulate the follicle and initiate cycling 13 of 13
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