Haematopoietic SC niche 0.0 / 5 ? BiologyRegenerative medicineUniversityAll boards Created by: DanielledarcyCreated on: 29-12-19 11:22 Where are the first haematopoietic stem cells found? In the embryonic yolk sac and aorta-gonad-mesenephros region 1 of 12 Where do HSCs migrate to before birth? To the bone marrow, where they will maintain haematopoiesis for the life of the organism 2 of 12 What does quiescence protect HSCs from? Damage and ensures long term survival 3 of 12 Where are dormant HSCs found? Around arterioles 4 of 12 What factors are secreted to promote HSC maintenance? CXCL12 and SCF (secreted by perivascular, endothelial, Schwann and sympathetic neuronal cells 5 of 12 Where are cycling HSCs found? Near sinusoidal niches which influence self-renewal, proliferation and differentiation 6 of 12 Which proteins are required to maintain HSCs? SCF and its receptor KIT (expressed by HSCs) 7 of 12 What does CXCL12 and CXCR4 signalling promote? HSC maintenance and retention in the bone marrow. As well as HSC engraftment following transplantation. 8 of 12 What does thrombopoietin do? Activates signaling by binding MPL on HSCs 9 of 12 Early experiments showed that increased numbers of bone-forming osteblasts... Led to increased numbers of HSCs 10 of 12 More recent research shows that... Any cell type in the BM can be ablated and induce an injury response 11 of 12 What effect does osteoblast ablation have on HSCs? None. HSCs only become depleted 2 weeks later. 12 of 12
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