GI Tract Related Pathology

Dyspepsia
Condition with symptoms like indigestion, pain/discomfort, bloating and belching. Can be caused by excess gastric acid or leakage of gastric acid or damage to gastric mucosal layer
1 of 22
GORD
Condition with symptoms like heartburn, acid reflux, dysphagia, chest pain. Caused by the abnormal relaxation of GO sphincter. Can also result in hiatus hernia
2 of 22
Hiatus hernia
Condition where part of your stomach moves up into your chest
3 of 22
Peptic ulcer
Condition with symptoms like indigestion, pain/discomfort, bloating and belching. May be due to H pylori, NSAID use, stress. Results in increase gastric acid secretion and reduction of mucous and HCO3-
4 of 22
Zollinger-Ellison Syndrome
A condition as a result of a gastrin-secreting tumour
5 of 22
Antacids
Dyspepsia treatment for symptomatic relief. It increases pH by neutralising gastric acid. Sodium bicarbonate, aluminium hydroxide (constipation), magnesium hydroxide (diarrhoea)
6 of 22
H2 receptor antagonist
GORD treatment. Prevents the release of histamine, not as effective as PPIs. Example: ranitidine
7 of 22
Proton pump inhibitor
GORD treatment. Prevents acid secretion by blocking H+/K+ATPase. Example: omeprazole, lansoprazole
8 of 22
Prostaglandin analogue
Peptic ulcer treatment. Increases secretion of mucous and HCO3-, inhibits acid secretion. Example: misoprostol (synthetic)
9 of 22
Alginates
Peptic ulcer treatment. These drugs produce a gel raft that protects the oesophagus from acid reflux
10 of 22
Antibiotics
H pylori infection treatment. Can be a 1 week triple treatment with a PPI combined with amoxycillin plus metronidazole or clarithromycin. Remission and reinfection possible
11 of 22
Carbon urea breath test
Diagnosis of H pylori presence. 14Carbon isotope urea is administered orally. Bacterial urease converts it to 14CO2 and it is breathed out. Breath is tested for radioactivity
12 of 22
Ulcerative colitis
An IBD. There is inflammation of the colon, with shallow but numerous ulcers in the mucosal layer. Leads to bloody diarrhoea and abdominal cramps
13 of 22
Crohn's disease
An IBD. Presence of ulcers in any part of GI tract, but mainly the bowel. Abscesses (painful collections of pus) and fissures (break in tissue layers).
14 of 22
IBS
Condition with recurrent abdominal pain with either diarrhoea or constipation. Absence of identifiable bowel pathology - microflora or psychological? Non-GI symptoms - lethargy, anxiety, depression
15 of 22
Aminosalicylates
Drug used in IBD, contains 5-ASA - an anti-inflammatory. Example: sulfasalazine - 5-ASA works locally but sulfapyridine absorbed. Mostly used in UC
16 of 22
Anti-inflammatories
Drugs used in IBD, mainly in conjunction with aminosalicylates. Effective for acute relapses. Corticosteroids or immunosuppressants. Example: Azathioprine
17 of 22
Biologics
Anti-TNF drugs (monoclonal antibodies). Use is restricted in the UK to severe CD that is unresponsive to other treatment. Drugs: infliximab
18 of 22
Antibiotics
Drugs used in IBD as it may be bacterial flora triggering the immune response which is causing the inflammation. Drugs: metronidazole
19 of 22
Anti-spasmodic agents
Drugs used in IBS which relieve gut spasm and associated pain by acting directly on GI smooth muscle. Anti-muscarinic effects. Drugs: alverine
20 of 22
Anti-depressants
Low dose of these drugs to treat IBS. Off-label use to treat abdominal pain. Selective serotonin re-uptake inhibitors (SSRIs) also used
21 of 22
5-HT receptor antagonists
Drugs to treat IBS. There are 5 HT (serotonin) receptors along the GI tract. Drugs: alosteron
22 of 22

Other cards in this set

Card 2

Front

Condition with symptoms like heartburn, acid reflux, dysphagia, chest pain. Caused by the abnormal relaxation of GO sphincter. Can also result in hiatus hernia

Back

GORD

Card 3

Front

Condition where part of your stomach moves up into your chest

Back

Preview of the back of card 3

Card 4

Front

Condition with symptoms like indigestion, pain/discomfort, bloating and belching. May be due to H pylori, NSAID use, stress. Results in increase gastric acid secretion and reduction of mucous and HCO3-

Back

Preview of the back of card 4

Card 5

Front

A condition as a result of a gastrin-secreting tumour

Back

Preview of the back of card 5
View more cards

Comments

No comments have yet been made

Similar Pharmacy resources:

See all Pharmacy resources »See all The Digestive System resources »