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6. How many populations does the HapMap Project phase 2 include

  • 4
  • 2
  • 143
  • 3

7. What does this describe? 20,000-25,000 genes, used to identify the 3 billion base pairs of our genome, to store information for all public

  • Human Genome Project
  • HapMap Project

8. what can selection bias cause

  • population stratification
  • information bias

9. 0 copy is...

  • commom homozygote
  • rare homozygote
  • heterozygote

10. 1 Copy is ....

  • Rare Homozygote
  • commom homozygote
  • heterzygote

11. What is the correct order for the historical overview of gene discovery?

  • Descriptive Epidemiology, segregation analyses, familial aggregation, heritability studies
  • Descriptive Epidemiology, familial aggregation, segregation analyses
  • Descriptive Epidemiology, familial aggregation, heritability studies, segregation analyses
  • Descriptive Epidemiology, heritability studies, familial aggregation, segregation analyses

12. What did segregation analyses do

  • estimated the genetic model of a disease by looking at the multigenerational family data
  • confirmed that environment was responsible for development of chronic disease
  • confirmed that genes cannot be segregated with the disease when it is translated

13. What is Descriptive Epidemiology?

  • Describing the disease and noticing that the DNA Genotype contributes to the DNA Phenotype as well as prevalence from different populations
  • Just a description of the disease and what symptoms it has
  • A description of the disease and its prevalence from one population to another

14. It can only look at common variants not rare ones is a disadvantage of what project?

  • HapMap Project
  • Human Genome Project

15. The main advantage of the HatMap Project is that it takes into consideration LD, but what is complete LD?

  • When the genetic variations are inherited together
  • When the genetic variations are inherited not together

16. If you were to do a case control status analysis e.g. disease and cut point what stats test would you do?

  • Logistic regression analysis (P value + odds value)
  • Linear Regression Analysis (P Value)

17. 2 copy is .....

  • Heterozygote
  • common homozygote
  • rare homozygote

18. Categorical and Quantitative are examples of what?

  • Outcomes
  • Exposure
  • Design
  • Co-variables

19. Co-founding is a disadvantage of candidate gene studies, but what is it?

  • when there is a third variable that affects exposure and disease outcomes and gives false findings e.g. ethnicity
  • when there is a second variable that affects the disease/ trait for example exposure
  • when there are many variables but these are all considered in the study

20. Is candidate gene studies hypotheses or not driven?

  • Hypothesis- driven
  • Non Hypothesis Driven