Gaba - continued 0.0 / 5 ? BiologyBiologyUniversityNone Created by: Annabel ForsdykeCreated on: 17-05-15 12:54 Agonist at the GabaA receptor Muscimol 1 of 15 Antagonists at the GabaA recetpor bicuculline, binds to the GABA binding site. Picrotoxin blocks the chloride channel. These cause convulsions 2 of 15 GABAa modulatory drugs Benzodiazapines bind at the site of interface of a and y subunits. Barbituates, neurosteroids, ethanol, anaestheitcs 3 of 15 What are GabaB receptors coupled to? Gi - to inhibit adenyl cyclase. and coupled to ion channels via the B/y subunits. 4 of 15 What is the pre-synaptic effect Long lasting inhibition of vg Ca2+ channels, decreasign transmitter release. 5 of 15 Where are they found, presynaptically? On glutamate and GABA containing terminals 6 of 15 Post synaptic inhibition effect increased opening of K+ channels to reduce firing of action potentials. 7 of 15 Where is glycine used as an inhibitory transmitter spinal cord, brain stem, retina, auditory systems, sensory systems. 8 of 15 How is glycine synthesised serine is catalysed to glycine by serine hydroxymethyl transferase. 9 of 15 How does glycine get in to vesicles H+ dependant vesicular inhibitory amino acid transporter 10 of 15 How is glycine reuptaken by glia - terminaates the action. By presynpatic transporter - reused. Driven by Na+ and Cl- gradients. 11 of 15 What is the Glycine receptor like A pentameric recetpor with 4 alpha subunits, and one type of B subunit. Glycine binds an an A subunit. Each subunit has 4 tmds 12 of 15 Name of a glycine receptor antagonist Strychnine. 13 of 15 How does picrotoxin inhibit non-competatively 14 of 15 What happens if there is a mutation in human glycine receptor Hyperekplexia. 100 fold decrease in glycine affinity, increased muscle tone and startle reflex 15 of 15
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