explanations for narcolepsy

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R T W E J R Y T N L X D D F N M
F O J D L K P U A P L F M R N J
C N N B E W O Q Y R H L A E B V
K G O N G U C B C H I K K M F V
N I T H E K R P X O N V G N S H
V M L J I X E H Q T M X C U A C
O B M T S Y T C N Q I H P V R Y
G N I D B V I Y H Y H K I S J B
E I H N O B N S I A P E C I O H
L S A U T O I M M U N E D A Q Y
Y H L I N K E D R B Q T W C Y A
W I T D Y A G Y N W A D R J T T
X N B H E J R S T Y H M Q H A Y
G O D V D V H S T B U U B Q F I
O Y P J T X Q M A D U L U A M I

Clues

  • ______(2000) found support that narcoleptic humans have a lower than normal level of hypocretin (7)
  • _______ et al (1997) found that the HLA variant found in narcoleptics is also found in the general population (6)
  • AO1: _____ regulates sleep and wakefulness by intercting with systems in the hypothalamus. narcoleptics have low levels of it. Therefore ____- and narcolepsy must be linked. (10)
  • AO1: a symptom of narcolepsy is a loss of muscle tone that is similar to what happens in_____. Narcoleptics also get intrusions of _______ in the day through hallucinations. Therefore narcolepsy could be because of a malfunction in the __ regulator. (3)
  • AO1: narcolepsy could be due to a mutated immune system. Narcoleptics have a higher frequency of _____ . It coordinates immune system responses. It's unclear how it leads to narcolepsy. (3)
  • AO2: who (1960) observed REM sleep in narcoleptic patients and saw that they experience it straight away (5)
  • AO2: who (1999) recorded neuron activity in narcoleptic dogs and showed that cataplexy occurs during REM brain cell activity (6)
  • it is likely that low hypocretin levels are due to brain injury, infection, diet, stress or due to an ___________ system attack. (10)
  • Mignot (2001) found that hypocretin and HLA are? This is because the HLA mutation affects the immune system and makes autoimmune conditions more likely. This cold result in a reduced level of hypocretin (6)

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