explanations for narcolepsy

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P H W H L A A U R L E A N A G U
V O G E L D E X T T S A I Q K W
J E S A Y X R E W N F E S C C Y
I F Q B Q J F V I G N M H D X E
M Y B H R U D T W U T P I T E L
F U I R C E E L M H W Y N U B Y
K X A B K R E M F B H I O P G J
C I S R C G I T J V C K F Q Q V
C K Y O E O I W T T D K Y L U P
Y Q P I T V S S O E M R P G E Q
I Y S U T V A N K E I W R N U A
H U A X F H G N R V W P H W V K
R Q H D O I I H A N J F C N V R
F D W L M L T P U S N D V C J E
I K Q J Y D J N G Y O A Y E W Y
J N U Y L X Y P U X N A S G C N

Clues

  • ______(2000) found support that narcoleptic humans have a lower than normal level of hypocretin (7)
  • _______ et al (1997) found that the HLA variant found in narcoleptics is also found in the general population (6)
  • AO1: _____ regulates sleep and wakefulness by intercting with systems in the hypothalamus. narcoleptics have low levels of it. Therefore ____- and narcolepsy must be linked. (10)
  • AO1: a symptom of narcolepsy is a loss of muscle tone that is similar to what happens in_____. Narcoleptics also get intrusions of _______ in the day through hallucinations. Therefore narcolepsy could be because of a malfunction in the __ regulator. (3)
  • AO1: narcolepsy could be due to a mutated immune system. Narcoleptics have a higher frequency of _____ . It coordinates immune system responses. It's unclear how it leads to narcolepsy. (3)
  • AO2: who (1960) observed REM sleep in narcoleptic patients and saw that they experience it straight away (5)
  • AO2: who (1999) recorded neuron activity in narcoleptic dogs and showed that cataplexy occurs during REM brain cell activity (6)
  • it is likely that low hypocretin levels are due to brain injury, infection, diet, stress or due to an ___________ system attack. (10)
  • Mignot (2001) found that hypocretin and HLA are? This is because the HLA mutation affects the immune system and makes autoimmune conditions more likely. This cold result in a reduced level of hypocretin (6)

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