Explanations of Narcolepsy 0.0 / 5 ? PsychologySleepA2/A-levelAQA Created by: Keyleigh-StormCreated on: 02-06-16 15:22 5211067489 Across 1. Recent research has found that more than 90% of people suffering from narcolepsy with cataplexy have been found to have the HLA ------- HLA-DQB1*0602. (7) 4. IDA - the artificial drugs won't result in a cure because the condition is merely controlled by continuously taking the drugs; the condition hasn't -----. (5) 7. HLA molecules are found on the surface of ----- blood cells and coordinate the immune response. (5) 8. Who found the 1st evidence for hypocretins came from narcoleptic dogs who were found to have a mutation in a gene on chromosome 12? The mutation had the effect of disrupting the processing of hypocretin. (3, 2, 2) 9. Who found increased frequency of one type of HLA (human leukocyte antigen) in narcoleptic patients? (5, 2, 2) Down 1. Who observed REM sleep at the onset of sleep in a narcoleptic patient, whereas it more commonly occurs later in the first cycle of sleep stages? (5) 2. In the 1960's an explanation offered for narcolepsy was that it was caused by a ---------- in the system that regulates REM sleep. (11) 5. It's possible in the future that transplanting hypocretin-producing cells may result in a ----. (4) 6. Who recorded neuron activity in the brainstream of narcoleptic dogs? This showed that cataplexy co-occurred with brain cell activity that usually only occurs in REM sleep. (6) 10. IDA - The fact that low hypocretin levels are implicated as a cause of narcolepsy suggests a cure is obvious (give sufferers a dose of hypocretins) but it's not that easy because the hypocretin molecule is relatively --------. (8)
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