Eukaryotic transcription factors continuted

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Describe the leucine zipper
Leu is every 7th amino acid, which is every second turn on the same side of the a helix. two interact and dimerise
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Examples of leucine zippers
CREB (cAMP responsive element, BDNF, VGF), C/EBP - liver
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How does the leucine zipper interact with DNA?
Doesn't bind directly, they have a basic region that binds DNA
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Describe helix-loop-helix.
Short a helix connect by a loop to a longer a helix. Often each helix has a basic dna binding domain. Dimerises
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Examples of helix-loop-helix factors
bHLH factors are involved in muscle development- MyoD acting on fibroblasts to form muscle cells., Neurogenin in neurogenesis.
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What regulates the binding of bHLH factors?
inhibitors that dont have a basic region. --> MyoD/ID
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How can transcription factors modify chromatin
HAT or HDAC activity
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Example of a tf that has histone acetylase activity
CBP that regulates genes in response to cAMP.
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An example of a tf that has histone deacetylase activity
thyroid hormone receptor co-repressor recruits a histone deaceylase
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What else does CBP do?
Help recruit RNA Pol II and act as a histone acetyl transferase
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How to target sites bind their condensed chromatin/
Pioneer transcription factors, eg GATA4, FoxA1
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Ways TFs are regulated
Tissue specific synthesis, regulation of splicing to generate different protein isoforms. , 3. Covalent modification, 4, release fromc ytoplasm,
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Example of alternative splicing in regulating TFs
Thyroid hormone receptor c-erbAa. C-erbAa-2 produced by alternative splicing and acts as a competative inhibitor of c-erbAa-1
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Card 2

Front

Examples of leucine zippers

Back

CREB (cAMP responsive element, BDNF, VGF), C/EBP - liver

Card 3

Front

How does the leucine zipper interact with DNA?

Back

Preview of the front of card 3

Card 4

Front

Describe helix-loop-helix.

Back

Preview of the front of card 4

Card 5

Front

Examples of helix-loop-helix factors

Back

Preview of the front of card 5
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