EPI and EEG

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  • Created by: molg
  • Created on: 20-05-18 13:45
seizure
manifestation of synchronisation and excessive firing from a population of cortical neurons
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Epileptogenesis
sequence of events that converts a normal neuronal network into a hyperexcitable circuit which triggers spontaneous seizures
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Status Epilepticus
medical emergencies characterised by 5 or more minutes of either continuous seizure activity or repetitive seizures with no recovery of consciousness/ can be generalised convulsive and non-convulsive
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convulsion
major motor manifestation of a seizure (rhythmic jerking of limbs)
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Aura
subjective and may be sensory or experiential that represents the start of certain seizures- a "warning"
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focal aware seizures- temporal lobe
unusual smell or taste / sudden intense feeling of fear or joy
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focal aware seizures - occipital lobe
visual disturbances (coloured or flashing lights ? hallucinations
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Proximal Depolarization shift (PDZ)
repetitive firing above threshold- producing prolonged APs
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epileptic patient recordings
Scalp EEG / Depth EEG
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brain slice recording
field / intra-cellular
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Generalised seizures
arising within and rapidly engaging bilaterally distributed networks
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Generalised- Atonic
falling limply to the ground
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Generalised- Tonic
going stiff and falling without convulsion
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Generalised- Tonic-clonic
Convulsion, going stiff and falling
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Generalised- myoclonic
short jerking movements of parts of the body
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Generalised- Absence
staring and blinking
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Focal seizures
originating within network / limited to one hemisphere- characterized according to one or more features: Aura, Motor, Autonomic: Awareness/responsiveness= altered or retained- may involved bilateral convulsive seizure
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Unknown seizure
insufficient evidence to characterse as focal, generalised or both- eg epileptic spasms
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EEG- electroencephalogram
captures voltage differences at scale (micro volts), ms resolution
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Beta bands
14-20 HZ- cortical
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Alpha bands
8-13 Hz- walking-quiet
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Theta bands
4-7 Hz- sleep states
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Delta bands
1-3 Hz- deep sleep
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Applications
diagnostic tool, monitoring tool, research tool
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Clinical use
1. detection of epileptic activity, sleep disorders, brain dysfunction
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MEG
measure changes in magnetic fields that accompany electrical activity
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Other cards in this set

Card 2

Front

sequence of events that converts a normal neuronal network into a hyperexcitable circuit which triggers spontaneous seizures

Back

Epileptogenesis

Card 3

Front

medical emergencies characterised by 5 or more minutes of either continuous seizure activity or repetitive seizures with no recovery of consciousness/ can be generalised convulsive and non-convulsive

Back

Preview of the back of card 3

Card 4

Front

major motor manifestation of a seizure (rhythmic jerking of limbs)

Back

Preview of the back of card 4

Card 5

Front

subjective and may be sensory or experiential that represents the start of certain seizures- a "warning"

Back

Preview of the back of card 5
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