Endocrinology LT 2 Calcium receptors

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  • Created by: emma
  • Created on: 09-12-13 16:52
Name the 3 calcitropic hormones
Calcitonin, PTH, 1,25(OH)2D3
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Type 1 PTHR is..
7 trans memembrane GPCR (class 2) - large ECD
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Where is the Type I PTHR expressed and what does it do
Bone and Kidney. mediates endocrine effects of PTH and paracrine effects of PTHrP
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type 2 PTH receptor..
51% identical to PTH1R, responds fully to PTH but binds PTHrP poorly and not simulated
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What pathways does the Type I PTHR effect
couples the Gs, AC, cAMP PKA pathway
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2 diseases caused by mutations of the PTH-R
Jansen's metaphyseal chondrodysplasia and Blomstrand's chondrodysplasia
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Describe Jansen's metaphyseal chondrodysplasia
Rare autosomall dominant disorder - short limbed dwarfism. Gain of function mutation. More sensistive leading to increased cAMP levels
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Describe Blomstrand's chondrodysplasia
rare autosomal recessive disorder, early lethality and advanced bone maturation. PTH1 inactivation mutation/deletion, prevents PTH-induced cAMP formation
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How is calcium a first and second messenger?
1st messenger, as blood calcium levels rise in response to increased PTH to feedback. Acts on parathyroid gland. Also messenger inside of cell.
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What do type I CaR agonists do?
Movement of Divalent cations Ca and Mg, spermine,, Gd3+ and aminoglycosides
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What do Type II CaR agonists do?
Allosteric activator (on own has no effect, increases sensitivity to calcium), calcimimetics (cinacalcet) Wand armoatic amino acids
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What do CaR antagonists do?
allosteric inhibitor, calcilytics
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Type 1 PTHR is..

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7 trans memembrane GPCR (class 2) - large ECD

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Where is the Type I PTHR expressed and what does it do

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type 2 PTH receptor..

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What pathways does the Type I PTHR effect

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