Endocrinology LT 2 Calcium receptors 0.0 / 5 ? BiologyCalcium receptorsUniversityAll boards Created by: emmaCreated on: 09-12-13 16:52 Name the 3 calcitropic hormones Calcitonin, PTH, 1,25(OH)2D3 1 of 12 Type 1 PTHR is.. 7 trans memembrane GPCR (class 2) - large ECD 2 of 12 Where is the Type I PTHR expressed and what does it do Bone and Kidney. mediates endocrine effects of PTH and paracrine effects of PTHrP 3 of 12 type 2 PTH receptor.. 51% identical to PTH1R, responds fully to PTH but binds PTHrP poorly and not simulated 4 of 12 What pathways does the Type I PTHR effect couples the Gs, AC, cAMP PKA pathway 5 of 12 2 diseases caused by mutations of the PTH-R Jansen's metaphyseal chondrodysplasia and Blomstrand's chondrodysplasia 6 of 12 Describe Jansen's metaphyseal chondrodysplasia Rare autosomall dominant disorder - short limbed dwarfism. Gain of function mutation. More sensistive leading to increased cAMP levels 7 of 12 Describe Blomstrand's chondrodysplasia rare autosomal recessive disorder, early lethality and advanced bone maturation. PTH1 inactivation mutation/deletion, prevents PTH-induced cAMP formation 8 of 12 How is calcium a first and second messenger? 1st messenger, as blood calcium levels rise in response to increased PTH to feedback. Acts on parathyroid gland. Also messenger inside of cell. 9 of 12 What do type I CaR agonists do? Movement of Divalent cations Ca and Mg, spermine,, Gd3+ and aminoglycosides 10 of 12 What do Type II CaR agonists do? Allosteric activator (on own has no effect, increases sensitivity to calcium), calcimimetics (cinacalcet) Wand armoatic amino acids 11 of 12 What do CaR antagonists do? allosteric inhibitor, calcilytics 12 of 12
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